动脉化疗在晚期卵巢癌治疗中的价值  

Evaluation of Transarterial Chemotherapy in Advanced Ovarian Cancer

作　　者：成佳景[1] 黄蕴思[1] 

机构地区：[1]同济大学附属铁路医院妇产科,上海200072

出　　处：《同济大学学报（医学版）》2001年第5期39-40,44,共3页Journal of Tongji University(Medical Science)

摘　　要：目的　探讨晚期卵巢癌先动脉灌注化疗再手术治疗的效果。方法　对 2 8例有腹水、包块较大的Ⅲ期以上的卵巢癌及复发的晚期卵巢癌患者先行腹壁下动脉插管灌注化疗 1至 2个疗程后再行手术。结果　化疗 15～ 30d ,有 16例腹水消退 ,病灶缩小 5 0 %以上 ;化疗 >30d ,有 9例腹水消退 ,病灶直径缩小不足 5 0 % ,但超过2 5 % ;化疗 6 0d ,有 6例效果明不显。化疗后再手术 ,近期有效率为 80 .6 % ,手术切净率为 6 0 .0 %。结论　动脉化疗使腹水消退 ,肿瘤体积、范围缩小 ,为施行满意的肿瘤细胞减灭术创造了条件 ,提高了手术切净率。Objective To evaluate the results of preoperative chemotherapy via artery in advanced ovarian cancer.Methods 28 advanced ovarian cancer patients who had ascites, large lumps or recurrences after one or two courses of general chemotherapy were treated by intervention chemotherapy via inferior epigastric artery , so as to provide an opportunity for further operation. Clinical observation was made.Results After 15-30 days of chemotherapy, 16 patients' ascites eliminated, and the lumps reduced over 50%.. After more than 30 days chemotherapy, nine patients' ascites eliminated and the lumps reduced 25-50% in size. Six patients who had had intervention chemotherapy for over 60 days had no obvious effects. Most patients later were tolerated the operations, the effective rate in short terms being 80.6% and the total excision rate,60%.Conclusion Preoperative chemotherapy via artery might eliminate ascites, reduce the bulk and the range of the lumps in most advanced ovarian cancers, and thus creates conditions for further radical operations and gives a better results including the rate of total excision, rate of survival and quality of life.

关 键 词：晚期卵巢肿瘤 动脉插管化疗 治疗效果 再手术 

分 类 号：R737.31[医药卫生—肿瘤] R730.5[医药卫生—临床医学]