苯那普利降尿蛋白时对肾病幼鼠肾功能的影响  

Benazepril effects on renal function in young rats with nephropathy when reducing proteinuria

作　　者：胡波[1] 李红叶[1] 杨霁云[1] 丁洁[1] 张敬京[1] 

机构地区：[1]北京大学第一医院儿科

出　　处：《实用儿科临床杂志》2001年第5期266-268,共3页Journal of Applied Clinical Pediatrics

基　　金：中华医学基金会医学师资奖学金(CMB)资助项目 (项目编号 :93593)

摘　　要：目的　观察血管紧张素转换酶抑制剂苯那普利对幼龄肾病大鼠起降尿蛋白作用的同时对其肾功能的影响。方法　将SD幼龄大鼠 (1个月龄 ,体重 10 0 g左右 )行单侧肾切除后加阿霉素 (5mg/kg)注射建立动物模型 ,术后即给予苯那普利 6mg/ (kg·d)治疗 12周 ,观察大鼠尿蛋白及血肌酐、尿素氮的变化。 结果　治疗第7、9、12周 ,苯那普利组尿蛋白与同期模型组相比分别为 (7.4± 4.4)、(2 .0± 1.2 )、(5 .2± 3.5 )mg/ 2 4h比 (14.4± 1.8)、(17.5± 10 .0 )、(15 .2± 4.7)mg/ 2 4h(P均 <0 .0 1)。苯那普利组与模型组肾功能相比 :实验中期 ,血尿素氮为 (11.1± 2 .5 )mmol/L比 (8.5± 1.9)mmol/L ;实验结束 ,血肌酐为 (6 3.8± 6 .3) μmol/L比 (5 4.5± 6 .3)μmol/L(P均 <0 .0 5 )。结论　在单侧肾切除后 1周注射阿霉素的幼龄肾病大鼠模型上 ,苯那普利在实验过程中显示降尿蛋白作用的同时 ,尚致血肌酐或尿素氮升高 ,此点值得重视。Objective To observe the effects of benazepril, an angiotensin converting enzyme inhibitor (ACEI), on renal function while it reduces proteinuria in a young rat with nephropathy.Methods Animal model was made by uninephrectomy and adriamycin (5 mg/kg) injection in SD young rats (one-month-old , weighing 100 g±). After uninephrectomy, the young rats were treated with benazepril 6 mg/(kg·d) for 12 weeks. The proteinuria, the serum creatinine and blood urea nitrogen were measured at regular intervals.Results Benazepril group was compared with model group:at 7,9 and 12 weeks, proteinuria was(7.4±4.4)vs (14.4± 1.8), (2.0±1.2)vs (17.5±10.0) and (5.2±3.5)vs (15.2±4.7)mg/24 h respectively, (P<0.01); the serum creatinine was (63.8±6.3)μmol/L vs (54.5±6.3)μmol/L in the mid-term of experiment and blood urea nitrogen was (11.1±2.5) mmol/L vs (8.5±1.9) mmol/L at the end of experiment respectively (P<0.05).Conclusion These results indicate that benazepril resultes in a increase of the serum creatinine or blood urea nitrogen while it reduces the proteinuria in the animal model made by injecting adriamycin after one week of uninephrectomy in SD young rats.

关 键 词：苯那普利 蛋白尿 肾功能 幼龄大鼠 

分 类 号：R965[医药卫生—药理学]