卵巢肿瘤患者红细胞与白细胞免疫功能变化及相互调控的实验研究  

The Experimental Study on the Change and Modulation of Erythrocytes and Leukocytes Immune Function in the Patients with Ovarian Tumor

作　　者：彭新萍 郭峰[2] 崔英[2] 张俊洁[2] 王海滨[2] 

机构地区：[1]湖北宜昌市第一医院,湖北宜昌443000 [2]第二军医大学长海医院,上海200433

出　　处：《实用妇产科杂志》2001年第5期286-287,共2页Journal of Practical Obstetrics and Gynecology

基　　金：国家自然科学基金资助 (基金编号396 70 75 4)

摘　　要：目的 :探讨红细胞和白细胞免疫功能变化及相互调控与卵巢肿瘤发病之间的关系。方法 :采用肿瘤红细胞淋巴细胞混合花环试验测定 5 1例卵巢癌、43例卵巢囊肿患者及 40例正常人红细胞、淋巴细胞免疫粘附肿瘤细胞能力 ;采用 3H- Td R掺入法测定淋巴细胞转化率及 NK细胞活性。结果 :卵巢癌患者肿瘤红细胞花环率 (TER)、肿瘤淋巴细胞花环率 (TL R)、肿瘤红细胞淋巴细胞混合花环率 (TEL R)、红细胞对淋巴细胞免疫粘附肿瘤细胞能力的促进率、淋巴细胞转化率及 NK细胞活性均低于卵巢囊肿患者及正常人 (P<0 .0 5或 <0 .0 1)。结论 :卵巢癌患者存在红细胞和白细胞免疫功能低下与紊乱 ,两者相互联系 ,互为调控 ,通过提高红细胞的免疫功能 。Objective:To study the relationship between the changes and modulation of erythrocytes and leukocytes immune function and ovarian tumor.Methods:Tumor erythrocyte lymphocyte rosette test and incorporation of 3H TdR was used as the ability of erythrocytes and lymphoctytes immunoadhering tumor cells,lymphocyte transformation rate and activety of natural killer cell of 51 patients with ovarian cancer,43 patients with ovarian cyst and 40 healthy persons.Results:Tumor erythrocyte rosette rate(TER),tumor lymphocyte rosette rate(TLR) and tumor erythrocyte lymphocyte rosette rate(TELR),ability of erythrocyte on enhancing lymphocyte immunoadhering tumor cells (ER),lymphocyte transformation rate and activity of natural killer cell in patients with ovarian cancer was significantly lower than that of patients with ovarian cyst and healthy persons( P <0.05 or <0.01).Conclusion:The erythrocyte and leukocyte immune function of patients with ovarian cancer is depressed.The erythrocytes immune function of patients with ovarian cancer is related to leukocytes immune function,and they modulate each other.Both of them play an important role in anti tumor immunity.

关 键 词：红细胞 白细胞 卵巢肿瘤 免疫功能 实验研究 

分 类 号：R737.31[医药卫生—肿瘤]