放化疗联合治疗食管癌  

Radiotherapy plus chemotherapy for esophageal carcinoma

作　　者：刘劲松[1] 王建华[1] 张景伟[1] 沙永慧[1] 

机构地区：[1]河南省肿瘤医院,郑州450003

出　　处：《中国肿瘤临床与康复》2001年第3期43-45,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的　研究放、化疗联合治疗食管癌的临床价值。方法　 12 0例食管鳞癌患者 ,随机分为 3个组行前瞻性临床研究。化疗组 40例 ,用 5 Fu、DDP、HCPT联合方案化疗 ;放疗组 40例 ,8MV X射线常规三野等中心照射 ,DT60Gy、DT2Gy/次、5次 /周 ;综合组 40例 :联合应用放、化疗方案。结果　化疗组、放疗组的 1、2、3年生存率分别为 :5 2 .5 %、3 2 .5 %、15 % ;5 7.5 %、42 .5 %、2 0 % ,综合组 1、2、3年生存率为 :75 %、65 %、42 .5 % ,综合组的 2、3年生存率明显高于放疗组 ,化疗组 (P <0 .0 5 )且无严重毒副作用。结论　食管癌放、化疗联合治疗疗效好 ,提高了 3年生存率 ,无严重副作用 ,值得进一步深入研究。Objective To study the therapeutic effect of radiotherapy with chemotherapy for esophageal carcinoma.Methods A prospective study was carried out in 120 patients,of whom 40 paitents were randomized into chemotherapy group,given 5-Fu DDP HCPT; 40 patients were randomized into radiotherapy group given 8MV-x ray using 3 fields to D T60Gy,40 patients were randomized into radiotherapy plus chemotherapy group given radiotherapy with chemotherapy.Three groups were followed for 3 years.Results The one,two and three-year survival rates were 52.5%,32.5%,15% in chemotherapy group,57.5%,42.5%,20% in radiotherapy group and 75%,65%,42.5% in chemo-radiotherapy group,respectively.The two and three-year survival rates in chemo-radiotherapy were much better than those in chemotherapy and radiotherapy (P<0.05).No severe side-effect was seen.Conclusions Chemoradiotherapy for esophageal carcinoma is effective and worth further studying in clinic.

关 键 词：食管癌 放射治疗 化学治疗 综合治疗 

分 类 号：R735.1[医药卫生—肿瘤]