腹腔内灌注化疗治疗癌性腹水  

Intraperitoneal chemotherapy for malignant ascite

作　　者：张骏[1] 连正杰[1] 

机构地区：[1]铁道部北京铁路总医院肿瘤中心,北京100038

出　　处：《中国肿瘤临床与康复》2001年第3期55-56,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的　探讨腹腔内灌注化疗治疗癌性腹水的临床效果。方法　对 3 8例癌性腹水患者 (其中原发肿瘤胃癌16例 ,乳腺癌 10例 ,大肠癌 8例 ,卵巢癌 4例 )采用腹腔穿刺置管方法使癌性腹水尽可能排出。腹腔内注入化疗药 :DDP70～ 10 0mg ,ADM 5 0～ 70mg ,MMC16～ 2 0mg ,5 Fu10 0 0～ 15 0 0mg。 结果　本组总有效率为 65 .8%。随访时间均超过 6个月。腹水缓解期超过 6个月以上者为 71.1% (2 7/ 3 8) ,毒性反应为食欲减退、恶心、呕吐者 2 1.1% ,其次为腹痛、发热等 ,一般采用对症治疗均可缓解 ,骨髓抑制多在 2 0天后恢复。结论　腹腔内灌注化疗治疗癌性腹水具有疗效好、毒性低、费用少等特点 ,是值得推广的治疗方法。Objective To evaluate the effect of intraperitoneal chemotherapy on malignant ascite.Methods 38 cases with ascite(16 gastric cancer,10 breast cancer,8 bowel cancer and 4 ovarian cancer) were firstly drained as much as possible, and then the drugs (DDP 70～100mg,ADM 50～70mg,MMC16～20mg and 5-FU1000～1500mg)were infused into abdominal cavity.Results The total effective rate was 65.8% and the patients were followed up for more than 6 months.CR+PR were 71.1%(27/38).The side-effects including anorexia, nausea,vomiting and abdominal pain, were alleviated by general treatment.Conclusions Introperitoneal chemotheraphy is effective in treating malignant ascite with few side-effects,low-cast.

关 键 词：癌性腹水 灌注化疗 治疗 

分 类 号：R730.5[医药卫生—肿瘤]