原发性肝癌危险因素的病例-对照研究  

A CASE CONTROL STUDY ON RISK FACTORS OF HCC IN QIDONG,CHINA.

作　　者：陈爱民[1] 徐耀初[2] 沈靖[2] 钮菊英[2] 张宝初 朱源荣 

机构地区：[1]上海市计划生育科学研究所流行病室,上海200032 [2]南京医科大学流行病学教研室,南京210029 [3]江苏省启东市肝癌研究所,启东226200

出　　处：《现代预防医学》2001年第3期299-301,共3页Modern Preventive Medicine

摘　　要：目的 :研究肝癌 (HCC)高发区江苏启东各危险因素的作用大小及相关性。方法 :对 6 6对肝癌患者和对照进行 1∶ 1配比病例对照研究 ,采用条件 L ogistic回归分析来分析以下 13个变量的作用 :肝炎史、肝硬化、肝癌家族史、既往饮水类型、食用腌制品、饮酒、 HBs Ag、抗 - HBc、抗 - HBe、抗 - HBs、 HBV DNA和抗 - HCV。结果 :单因素分析揭示肝炎史、肝硬化、肝癌家族史、既往饮水类型、饮酒、 HBs Ag、抗 - HBc、抗 - HBe、抗 - HBs和 HBV DNA有显著性差异 ,多因素分析得到三个有统计学意义的模型。结论 :在肝癌高发区启东市 ,乙型肝炎病毒 (HBV )感染、既往饮水类型、肝癌家族史和饮酒是肝癌的主要危险因素 ,丙型肝炎病毒 (HCV )Objective:To investigate the role of risk factors of Hepatocellular Carcinoma(HCC) in Qidong.Method:A 1∶1 matched case control study was conducted,and 66 HCC cases and their individually matched controls were included in this study.Thirteen independent variables were selected to be analyzed by conditional logistic regression,which are hepatitis,cirrhosis,family history of HCC,former drinking water type,eating pickled food,habitual alcohol drinking,HBsAg,HBeAg,anti HBc,anti HBe,anti HBs,HBV DNA and anti HCV.Result:Simple conditional logistic regression analysis demonstrated that hepatitis,cirrhosis,family history of HCC,former drinking water type,habitual alcohol drinking,HBsAg,anti HBc,anti HBe,anti HBs and HBV DNA showed significant difference between case group and control group.There are three significant model of multiple logistic regression analysis.Conclusions:in Qidong,hepatitis B virus(HBV) infection,former drinking water type,family history of HCC and habitual alcohol drinking were the major risk factors of HCC in Qidong City China.Hepatitis C virus(HCV) infection wasnt related with HCC there.

关 键 词：原发性肝癌 危险因素 病例-对照研究 LOGISTIC回归 流行病学 

分 类 号：R735.701[医药卫生—肿瘤]