白细胞介素-1受体拮抗剂对角膜碱烧伤治疗的实验研究  

Study of the therapeutical effect of IL-1ra on corneal alkali burn

作　　者：任华[1] 单清[1] 张杰[1] 王登龙[1] 姜严明[1] 钱焕文[1] 

机构地区：[1]军事医学科学院放射医学研究所,北京100850

出　　处：《眼科研究》2001年第5期392-395,共4页Chinese Ophthalmic Research

摘　　要：目的 系统观察研究白细胞介素－１受体拮抗剂（ＬＩ－１ｒａ）对角膜碱烧伤的治疗作用。方法 采用日本大耳白兔及Ｗｉｓｔａｒ大鼠，制成角膜碱烧伤模型。通过裂隙灯与病理组织学观察，进行角膜ＯＤ值与角膜上皮细胞活性测定，烧伤斑图像分析，以及ＩＬ－１酶联免疫吸附测定（ＩＬ－１ ＥＬＩＳＡ）。结果 应用ＩＬ－１ｒａ后兔角膜水肿程度减轻，角膜ＯＤ值较大，角膜上皮细胞活性恢复较好。并能明显抑制大鼠角膜中的ＩＬ－１水平。结论 ＩＬ－１ｒａ能抑制炎症反应，有利于角膜透明度和上皮细胞活性恢复。Objective To study the treatment of animal cornea alkali burn by Interleukin-1 receptor antagonist(IL-1ra). Methods Cornea of rabbits and rats were burned by alkali. Six items including the observation of slit-lamp and pathology,deter- mination OD value of cornea and activity of corneal epithelial cell,cornea burn image analysis and IL-1 ELISA were used to exam- ine the therapeutic effect of IL-1ra. Results IL-1ra can control inflammation and is beneficial to recovery of rabbits corneal transparency and epithelial cell activity. IL-1ra can also inhibit IL-1 level of rats. Conclusion IL-1ra was therapeutic in corne- al alkali burn.

关 键 词：白细胞介素-1受体拮抗剂 角膜碱烧伤 LI-lra 治疗 

分 类 号：R779.13[医药卫生—眼科] R772.2[医药卫生—临床医学]