FDG-PET在胶质瘤复发诊断中的临床应用  

Clinical application of FDG PET for the diagnosis of recurrence in glioma

作　　者：左传涛[1] 刘永昌[1] 管一晖[1] 赵军[1] 林祥通[1] 

机构地区：[1]复旦大学附属华山医院,上海200040

出　　处：《核技术》2001年第11期899-902,共4页Nuclear Techniques

摘　　要：为评价18FDG -PET在胶质瘤复发和坏死鉴别诊断中的价值 ,对经手术治疗或放射治疗后的脑胶质瘤患者 15例进行PET检查。结果表明 ,随访证实复发的 12例胶质瘤患者中 ,11例的FDG -PET显像结果提示肿瘤复发 ,另外未复发的 3例患者 ,FDG -PET结果提示无复发。FDG-PET显像表明 ,胶质瘤复发可以表现为原发部位片状、环状、点状FDG摄取及远隔部位FDG摄取增高。肿瘤复发病变最高放射性浓度比平均白质放射性浓度的比值为 2 .85± 1.0 ,而未复发或放射性改变组织的最高放射性浓度比平均白质放射性浓度的比值为 1.32± 0 .0 7,两者之间差异显著 (P <0 .0 5 )。结果提示 ,FDG -PET显像有助于胶质瘤放射治疗后患者放射性坏死和复发的鉴别。To evaluate the role of 18 FDG-PET in the differential diagnosis of recurrence and radionecrosis in glioma. FDG-PET scans in 15 glioma patients were performed after initial surgery and radiation therapy. Results of the 12 tumor recurrence, 11 FDG-PET scans showed hypermetabolism, 3 patients with hypometabolic abnormalities on FDG-PET scan had no evidence of recurrence. In recurrence, the primary site showed platelike, ringform and tocal FDG uptake and also increased uptake in remote area. In tumor recurrent patients, the lesion's highest radioactivity/average white matter radioactivity ratio was 2.85±1.0, while the ratio of radionecrosis was 1.32±0.07, the differences were significant. Conclusions show that FDG-PET scans are helpful in the differentiation between tumor recurrences and radionecrosis in glioma.

关 键 词：PDG-PET 胶质瘤 复发 放射性坏死 诊断 神经系统肿瘤 

分 类 号：R739.41[医药卫生—肿瘤] R730.4[医药卫生—临床医学]