^(99)Tc^m-MIBI肿瘤阳性显像的临床应用  

The Clinical Application of Tumors Positive Imaging With ^(99)Tc^m-MIBI

作　　者：游金辉[1] 吴成明[2] 张涛[1] 吴成秀[1] 谢建平[1] 孙跃军[1] 

机构地区：[1]川北医学院附属医院核医学科,四川南充637007 [2]川北医学院附属医院肿瘤科,四川南充637007

出　　处：《同位素》2001年第3期250-253,共4页Journal of Isotopes

基　　金：四川省南充市科委课题 (南市科发 (1 999) 1 5号;项目编号 :0 5 )

摘　　要：探讨了 99Tcm- MIBI肿瘤阳性显像在多种恶性肿瘤临床诊断中的应用价值。静脉注射 99Tcm-MIBI15～ 30 min后 ,用美国 GE公司 SPX- 6型 SPECT行病变局部平面和断层显像 ,计算肿瘤与本底比值 (T/ B) ,当 T/ B≥ 1.5时判定显像结果为阳性 ;肝脏肿瘤诊断则比较胶体显像和阳性显像时肿瘤部位是否有填充 ,若有填充则为阳性。 2 1例受检者中病理诊断为恶性肿瘤 17例 ,良性肿瘤 4例。 17例恶性肿瘤 99Tcm - MIBI阳性显像 15例阳性 ,2例阴性 ;4例良性肿瘤患者显像结果均为阴性。本组病例 99Tcm- MIBI阳性显像的敏感性为 88% ,特异性为 10 0 % ,阳性预测值为 10 0 % ,阴性预测值为 6 6 .7% ,准确率为 90 %。结果表明 99Tcm-The clinical values of tumors positive imaging with 99 Tc m MIBI is evaluated. The imaging results of twenty one patients with tumors pathologically determined are studied in 15～30 min after injection of 99 Tc m MIBI using GE SPX 6 SPECT. The ratio of tumor to background(T/B) is calculated, and the positive results are determined when T/B≥1.5. The positive results also are obtained when space occupy lesion(SOL) of liver in colloid imaging are filled in 99 Tc m MIBI imaging. Seventeen of twenty one (17/21) patients have malignant tumors and four of twenty one (4/21) patients have benign tumors in pathologic diagnosis. In which fifteen of seventeen (15/17) patients with malignant tumors are positive, two of seventeen (2/17) patients with malignant tumors are negative, and four of four (4/4) patients with benign tumors are negative diagnosed by SPECT with 99 Tc m MIBI. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of tumor positive imaging with 99 Tc m MIBI are 88%, 100%, 100%, 66.7% and 90%, respectively. It shows that tumor positive imaging with 99 Tc m MIBI appears to be a useful method for diagnosis of malignant tumors.

关 键 词：^99TC^M-MIBI 肿瘤 阳性显像 诊断 锝99 标记 放射性核素 

分 类 号：R730.44[医药卫生—肿瘤]