大肠癌高发区居民结肠癌危险因素研究  

Colon cancer risk factors in Jiashan county, Zhejiang province, the highest incidence area in China

作　　者：汪祥辉[1] 雷通海[2] 马新源 吕桂泉[2] 何兆毅[2] 姚开颜 李其龙 陈康 

机构地区：[1]浙江省肿瘤研究所,杭州310022 [2]浙江省肿瘤医院 [3]浙江省嘉善县肿瘤研究所

出　　处：《中华肿瘤杂志》2001年第6期480-482,共3页Chinese Journal of Oncology

基　　金：国家"九五"攻关课题 ( 96 90 6 0 1 0 1)

摘　　要：目的　研究我国结直肠癌最高发地区浙江嘉善县结肠癌危险因素 ,为监测和预防结肠癌提供科学依据。方法　采用以全人群为基础的病例对照研究 ,用统一的调查表调查了 10 9对结肠癌病例和对照 (病例对照之比为 1∶7) ,应用Logistic回归对结肠癌相关变量进行了单因素和多因素分析。结果　 10年前猪肉月均消耗量高 (OR =1.6 0 8)、10年前动物油月均消耗量高 (OR =1.391)、精神压抑 (OR =9.887)、负性情绪 (OR =1.72 3)、下消化系统疾病 (OR =4.16 3)和一级亲属结直肠癌史(OR =3 .42 1)是嘉善县结肠癌主要危险因素 ;10年前蔬菜月均消耗量高则为发生结肠癌的保护因素(OR =0 .42 2 )。结论　嘉善县结肠癌与饮食因素有关。研究结果支持结肠癌发生的脂肪胆汁酸假说及纤维缺乏假说。精神压抑、遗传和下消化系统疾病也与结肠癌发病密切相关。Objective To investigate the risk factors of colon cancer in the highest incidence area, Jiashan county, providing scientific basis for monitoring and prevention.Methods With a population based case control study, 109 colon cancer patients with 1∶7 matched controls were interviewed with uniform questionnaires. Conditional logistic regression was used for univariate and multivariate analysis of colon cancer.Results Ten years before, high monthly pork consumption ( OR =1.608), high monthly animal oil consumption ( OR =1.391), psychological depression ( OR =9.887), negative emotion ( OR =1.723), lower digestive tract diseases ( OR =4.163), and history of colorectal cancer in the first degree relatives ( OR =3.421) were the main risk factors of colon cancer. At that time, high monthly vegetable consumption was a protective factor for colon cancer ( OR = 0.422). Conclusion Colon cancer in Jiashan county was related to dietary factors. The research results support the colon cancer etiological hypothesis of 'fat bile acid' and 'deficiency of dietary fibres'. Psychological depression, inheritance and lower digestive tract diseases were also correlated with colon cancer. [

关 键 词：大肠癌 结肠癌 危险因素 流行病学 病例对照研究 

分 类 号：R735.3[医药卫生—肿瘤]