三氧化二砷注射液治疗中晚期原发性肝胆癌的临床研究  

Arsenic trioxide in the treatment of advanced primary liver and gallbladder cancer

作　　者：钱军[1] 秦叔逵[1] 何泽明[1] 王琳[1] 陈映霞[1] 邵志坚[1] 刘秀峰[1] 

机构地区：[1]解放军第八一医院全军肿瘤中心内科,南京210002

出　　处：《中华肿瘤杂志》2001年第6期487-489,共3页Chinese Journal of Oncology

基　　金：江苏省青年科技基金资助项目 (BQ980 48) ;南京军区重点科研基金资助项目 (NJ980 4)

摘　　要：目的　评价三氧化二砷 (As2 O3)治疗原发性肝胆癌的疗效和不良反应。方法　中晚期原发性肝胆癌共 33例 ,其中肝癌 2 9例 ,胆囊癌 4例。单药As2 O3 注射液 15mg ,静脉滴注 ,1次 /d ,连用14～ 2 1d为一周期 ,间歇 2周重复。结果　总缓解率 15 .2 % ,其中原发性肝癌PR 4例 ,NC 2 1例 ,PD 4例。缓解率 13 8% ;胆囊癌CR 1例 ,NC 2例 ,PD 1例。主要不良反应为轻度的骨髓抑制和肝功能损害。结论　As2 O3 治疗原发性肝胆癌有较好疗效 ,不良反应少 ,值得进一步深入研究。Objective To evaluate the effect and toxicity of arsenic trioxide (As 2O 3) in treating primary liver and gallbladder cancer.Methods Twenty nine advanced primary liver cancer and 4 gallbladder cancer patients were treated with As 2O 3 injection only, 15 mg iv qd for 14 21 days and was repeated after 2 weeks.Results The overall response rate was 15.2%, 13.8% in primary liver cancer (PR 4, NC 21 and PD 4). It was 25.0% in gallbladder cancer (CR 1, NC 2, PD 1). The major side reactions were mild bone marrow suppression and hepatic functional damage. Conclusion As 2O 3 injection is effective in treating primary liver and gallbladder cancer with mild side reactions. It is worth studying in the future. [

关 键 词：肝肿瘤 药物疗法 胆囊肿瘤 三氧化二砷 治疗 疗效 

分 类 号：R735.7[医药卫生—肿瘤] R735.8[医药卫生—临床医学]