乙酰氯法合成对-乙酰基苯甲醚  

SYNTHESIS OF p-METHOXYACETOPHENONE BY ACETYLCHLORIDE METHOD

作　　者：陈光勇[1] 李安良[2] 刘晓波[1] 严亚[1] 

机构地区：[1]大理医学院药学系,云南大理671000 [2]北京大学药学院,北京100083

出　　处：《华西药学杂志》2001年第5期362-362,共1页West China Journal of Pharmaceutical Sciences

摘　　要：目的 :改进对 乙酰基苯甲醚的合成工艺。方法 :以苯甲醚为原料 ,乙酰氯作酰化剂 ,无水AlCl3 作催化剂 ,控制反应温度 ,经乙醚提取 ,干燥 ,减压蒸馏得产品。结果 :收率从醋酐法的 93.3 %提高到 96 .7%。结论 :本法收率较高且稳定 ,反应条件温和 ,是一种合成对OBJECTIVE:To improve the synthetic technique.METHODS:The reaction was carried out under the conditions of taking phenylmethyl ether as the synthetic material, acetylchloride as the acetylization agent, aluminium chloride anhydrous as the catalyst, and controlling the reactive temperature. The final products were extracted by ether, dried, then distilled in vacuum, the purified p methoxyacetophenone was obtained.RESULTS:The product rate could be raised from 93.3% to 96.7%.CONCLUSION:This method has high product rate and its reactive conditions are mild and steady.

关 键 词：合成工艺 对-乙酰基苯甲醚 苯甲醚 乙酰氯 药物中间体 

分 类 号：TQ460.4[化学工程—制药化工] R914[医药卫生—药物化学]