人类乳头瘤病毒与宫颈糜烂癌变的相关性研究  

The Correlation Between Human Papillomavirus and Cervical Erosion for Carcinogenesis

作　　者：陈富强 符玉良[2] 王自能[3] 

机构地区：[1]无锡市锡山人民医院妇产科,江苏无锡214011 [2]广州市妇婴医院生殖医学研究所,广东广州510180 [3]暨南大学医学院附属医院妇产科,广东广州510632

出　　处：《肿瘤防治杂志》2001年第4期342-344,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :探讨人类乳头瘤病毒与宫颈糜烂癌变的相互关系。方法 :阴道镜下对 116例宫颈糜烂 ,12例宫颈癌及 36例正常宫颈分别钳取活组织 ,用聚合酶链反应对活组织进行HPV公共引物及HPV16、HPV18型特异引物检测。结果 :2 9.31%的宫颈糜烂患者HPV阳性 ,正常宫颈阳性率仅 11.11% (P <0 .0 5) ,宫颈糜烂Ⅰ度、Ⅱ度、Ⅲ度及宫颈癌中HPV16是最常见亚型 ,其阳性率分别为 9 38%、18 90 %、2 5 53%、75 0 % ,宫颈颗粒型或乳突型糜烂与宫颈癌强相关 (OR =5 56,95%CI =1 2 1～ 2 5 4 9)。“高危”HPV DNA检出率随宫颈鳞柱上皮异位程度增加而升高。结论 :宫颈糜烂的病因可能与持续感染“高危”HPVs有关。Objective To determine the correlation between human papillomavirus and cervical erosion for carcinogenesis.Methods 116 cases with cervical erosion and 12 cases with cervical cancer underwent cervical biopsy by colposcopy.HPV consensus primer and HPV 16 、HPV 18 type specific primers were used in polymerase chain reaction(PCR) to detect HPV s DNA.In addition 36 normal cervix biopsy samples were also tested with the same method.Results 29.31% of cervical erosions were positive with HPV consensus primers compared with 11.11% in normal( P <0.05),in cervical erosion grade Ⅰ,Ⅱ,Ⅲ and cervical carcinoma,HPV 16 DNA was frequently detected,with positive ratios 9.38%,18.90%,25.53% and 75.00% respectively.The data suggested cervical erosion especially the granular/papillar type was strongly association with cervical carcinoma(OR=5.56,95%CI=1.21-25.49),the“high risk 'HPV 16 /HPV 18 DNA was increasingly detected in cervical erosion as the columnar cell ectopy increased.Conclusion Persisting infection of“high risk'HPVs might be the causal for erosion carcinogensis.

关 键 词：宫颈糜烂 宫颈肿瘤 人类乳头瘤病毒 聚合酶链反应 

分 类 号：R737.33[医药卫生—肿瘤]