大蒜素对豚鼠心室乳头肌电和机械活动的影响  

EFFECT OF ALLITRIDI ON ELECTRIC AND MECHANICAL ACTIVITY OF GUINEA PIG'S PAPILLARY MUSCLES

作　　者：程伟[1] 喻荣辉[2] 屈松柏[1] 史载祥[3] 

机构地区：[1]湖北中医学院附属医院,武汉430061 [2]武汉市第一医院,武汉430000 [3]北京中日友好医院,北京100039

出　　处：《中国中医药科技》2001年第5期305-307,共3页Chinese Journal of Traditional Medical Science and Technology

基　　金：湖北省教委基金资助项目NO 940 31

摘　　要：为探讨大蒜素抗心律失常的机理 ,用细胞内玻璃微电极技术测定大蒜素对豚鼠乳头肌电生理的影响。结果 :在 1 2 5、62 5μmol/L ,肾上腺素阈浓度诱导的自律性提高 62 5μmol/L的浓度使收缩力减弱、强度一时间曲线部分右移。在 5、2 5、1 2 5、62 5μmol/L时 ,快反应动作电位振幅增加 ;而 62 5μmol/L ,30 %、50 %、90 %快反应动作电位的复极时间、有效不应期、刺激传导时间均延长 ,有效不应期 90 %复极时间增大。在 1 2 5、62 5μmol/L ,50 %、90 %慢反应动作电位的复极时间延长。结论 :大蒜素抗室性心律失常与其对乳头肌自律性、收缩性、兴奋性均有较弱的抑制作用及能延长动作电位时程 ,使乳头肌有效不应期与 90 %复极时间之比、刺激传导时间增大有关。Objective:To explore the effect of Allitridi on anti-arhythmia,cardiac electrophysiological characteristic were detected in guinea pig's papillary muscles by intracellular microelectrode technique. Result:The automaticity which adrenalin induces was inhibited at 125 and 625μmol/L.The force of contraction was weakened;the intensity-time curve which reflected excitability move partly towards right after 625μmol/L administration.Fast action potential amplitude was increased under all doses;fast action potential duration of 30%?50% and 90% repolarization effective refractory period and stimulating conductive duration are extended;the ratio of effective refractory preiod to fast action potential duration of 90% repolarization is enlarged at 625μmol/L;slow action potential duration of 50% and 90% repolarization are prolonged at 125 and 625umol/L. Conclusion:automaticity excitability contractibility and refractoriness not only are inhibited slightly but also action potential durations are extended;stimulating conductive duration and the ratio of effective refractory period to fast action potential duration of 90% repolarization is enlarged after Allitridi administrated.

关 键 词：大蒜素 药理学 心室乳头肌 药物作用 动作电位 电生理学 豚鼠 中药 

分 类 号：R285.5[医药卫生—中药学]