实验性变态反应性脑脊髓炎T淋巴细胞增殖和肿瘤坏死因子-α变化的意义  

Study on T Cell Proliferation, Tumor Necrosis Factor-α Abnormalities in Lewis Rats with Active Experimental Autoimmune Encephalomyelitis

作　　者：吕佩源[1] 宋春风[2] 高昌星[3] 井上敦[3] 

机构地区：[1]河北省人民医院神经内科,河北石家庄050051 [2]河北医科大学电镜实验中心,河北石家庄050017 [3]日本信州大学附属病院第三内科

出　　处：《中国神经免疫学和神经病学杂志》2001年第4期201-203,共3页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的　探讨实验性变态反应性脑脊髓炎 ( EAE) T淋巴细胞增殖和肿瘤坏死因子 ( TNF) -α变化的意义。方法　观察 Lewis大鼠主动免疫性 EAE临床症状、T淋巴细胞增殖以及血清 TNF-α水平。结果　 EAE临床发病过程中 ,T淋巴细胞增殖活跃 ,血清 TNF-α水平异常升高 ,并与临床症状呈正相关。结论　研究表明 :EAE时 ,T淋巴细胞增殖旺盛和 TNF-α生成增多 ,进而导致血脑屏障的破坏 ,炎细胞浸润 ,从而诱发 EAE。Objective To demonstrate the significance of T cell proliferation, serum tumor necrosis factor (TNF) α abnormalities during clinical course of experimental autoimmune encephalomyelitis (EAE) in Lewis rats.Methods The rats of EAE were examined for the development of neurological responses T cell proliferative and serum tumor necrosis factor (TNF) α concentrations.Results There were an active T cell proliferation, markedly TNF α increase which paralleled with clinical onset of EAE.Conclusions Our studies suggest that T cell proliferation and increasing TNF α production could result in blood brain barrier (BBB) breakdown,and inflammatory cell recruitment significantly and therefore EAE is induced.

关 键 词：多发性硬化 实验性变态反应性脑脊髓炎 T淋巴细胞增殖 肿瘤坏死因子-Α 

分 类 号：R744.3[医药卫生—神经病学与精神病学]