Mncl_2增强树突状细胞HLA-DR表达的研究  

Mncl_2 enhancing the expression of HLA-DR on DC

作　　者：黄少萍[1] 杨宁[1] 尹兰珍[1] 夏建春[1] 

机构地区：[1]东南大学基础医学院组织胚胎学教研室,南京210009

出　　处：《中国肿瘤临床与康复》2001年第5期47-48,共2页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：铁道部科技基金资助 (编号J99Z12 8)

摘　　要：目的　探索Mncl2 对树突状细胞 (Dendriticcells .DC)HLA DR表达的影响。方法　采用流式细胞仪分析Mncl2 刺激组及阴性对照组DC表面HLA DR表达水平及HLA DR阳性细胞率。结果　Mncl2 刺激组DC平均荧光强度为 165 .97,阴性对照组为 10 5 .72 (P <0 .0 1)。刺激组DC的HLA DR阳性细胞率为 89.96% ,阴性对照组为 78.73% (P<0 .0 1)。结论　Mncl2 在体外能显著增强DC表面HLA DR表达水平及总细胞HLA DR阳性细胞率。Objective To explore the impact of Mncl 2 on the expression of HLA-DR on DC. Methods The expression of HLA-DR on DC groups stimulated with Mncl 2 and the negative groups was evaluated by the flow cytometry. Results The general fluorescence intensity of DC groups stimulated with Mncl 2 was 165.97, however, that of negative groups was 105.72(P<0.01). The positive rate of HLA-DR expression in DC groups stimulated with Mncl 2 and in negative groups was 89.96%,78.73% respectively (P<0.01). Conclusion Mncl 2 can greatly increase the expression of HLA-DR on DC and also increase the positive rate of HLA-DR expression in DC groups.

关 键 词：树突状细胞 Mncl2 肿瘤 表达 

分 类 号：R73-36[医药卫生—肿瘤]