绿茶儿茶素与抗癌药联合应用对二株人肝癌细胞生长的影响  

Growth inhibition of human hepatocarcinoma cell lines by the combination of Green Tea Catechins and antitumor drugs

作　　者：刘术娟[1] 张乃鑫[1] 丁顺利[2] 褚建新[2] 赵天如[1] 

机构地区：[1]天津医科大学病理学教研室,300070 [2]中国医学科学院血液学研究所

出　　处：《天津医科大学学报》2001年第3期305-307,共3页Journal of Tianjin Medical University

基　　金：天津市自然科学基金资助 (编号 :973609411)

摘　　要：目的 :研究绿茶儿茶素 (GTC)与抗癌药阿霉素 (ADM)、5 -氟尿嘧啶 (5 -Fu)和阿糖胞苷 (AraC)联合应用对人肝癌细胞体外生长的抑制作用。方法 :应用MTT法检测GTC先于抗癌药、抗癌药作用后或与抗癌药同时作用 ,对BEL -7402和SMMC -7721人肝癌细胞的生长抑制作用。结果 :GTC与抗癌药有相加性抑瘤效应。结论Objective: To examine the effects of green tea catechins (GTC) with antitumor drugs such as adriamycin(ADM), 5-fluorouracil(5-Fu) and cytarabine(Arac) on the growth inhibition of BEL-7402 and SMMC-7721 human hepatocarcinoma cell lines. Methods: MTT colorimetric assay was used to examine the cell proliferation. Results: The results showed that combination of GTC and antitumor drugs potentiated the inhibitive effects on the hepatocarcinoma cells. Conclusion: It is suggested that GTC maybe a promising cancerous chemopreventive agent and chemotherapetic adjuvant.

关 键 词：绿茶儿茶素 人肝癌细胞 抗癌药 药理 

分 类 号：R979.1[医药卫生—药品] R735.705[医药卫生—药学]