达纳康对糖尿病视网膜病变眼视网膜光凝术所致眼前段早期改变的干预效果  

The effects of intervention with Tanakan on anterior ocular segment in diabetic retinopathy after retinal photocoagulation

作　　者：于强[1] 张欣[1] 柳青[2] 陈秀琦[1] 钟晓菁[1] 

机构地区：[1]中山医科大学中山眼科中心,广州510060 [2]中山医科大学中山公共卫生学院生物统计学教研室,广州510060

出　　处：《中华眼底病杂志》2001年第3期187-189,共3页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的　探讨达纳康对糖尿病视网膜病变 (diabetic retinopathy,DR)视网膜光凝术后眼前段改变的干预效果。　方法　采用前瞻性随机对照方法将 72例 DR患者的 72只视网膜光凝治疗眼 (DR ～ 期 )分为达纳康干预组和对照组。应用超声生物显微镜 (ultrasound biomicroscopy,UBM)观察和定量分析两组患者视网膜光凝术前、术后第 3、7d前房深度、前房角、睫状体和前段脉络膜的改变。　结果　术后第 3d,对照组视网膜光凝术眼眼压升高 ,与术前相比差异有显著性意义 (t=- 2 .82 1,P<0 .0 1) ;除鼻侧前房角外其余象限前房角较术前变窄 (t=2 .0 33～ 3.15 0 ,P<0 .0 1)。药物干预组视网膜光凝术眼眼压和各象限前房角均无显著改变。药物干预组睫状体脱离、前段脉络膜脱离的发生率分别为 11.11%、5 .5 6 % ,对照组分别为86 .11%、88.89%。药物干预组睫状体脉络膜脱离的高度亦显著低于对照组。　结论　达纳康能在一定程度上减少视网膜光凝术所致的睫状体脉络膜脱离和眼压升高、前房角变窄等眼前段并发症的发生率 ,减轻睫状体脉络膜脱离的程度。Purpose To investigate the effects of intervention with Tanakan on anterior ocular segment in diabetic retinopathy (DR) after retinal photocoagulation. Methods Prospective random controlled study was performed on 72 patients (72 eyes) with ultrasound biomicroscopy (UBM),by obtaining and quantitatively analyzing the changes of anterior ocular segment including anterior chamber, anterior chamber angle, ciliary body and choroids before and the 3rd day and the 7th day after retinal photocoagulation. Results Three days after photocoagulation, significant elevated IOP and narrowed chamber angle were observed in control group and 4 eyes (11.11%) in Tanakan group (P<0.01). Choroidal detachment in 32 eyes (88.89%) in control group and in 2 eyes (5.56%) in Tanakan group and the severity of ciliochoroidal detachment in tanakan group was significantly lower than that in control group. Conclusion Tanakan is effective to prevent the complications of anterior segment, such as ciliochoroidal detachment, elevation of IOP, narrowing of chamber angle occurring early after retinal photocoagulation and reduce the severity of ciliochoroidal detachment.

关 键 词：糖尿病视网膜病变 激光凝固术 银杏科 药物作用 萜类 达纳康 

分 类 号：R774.1[医药卫生—眼科]