40%尿素溶液在犬胰左叶缺血中的应用研究  

EFFECT OF 40% UREA SOLUTION ON THE ISCHEMIA OF LEFT PANCREAS LOBE IN DOG

作　　者：向国安[1] 耿智敏[2] 孙水平[1] 秦兆寅[3] 胡海田[1] 郑克让[1] 杨文彬[3] 

机构地区：[1]陕西省人民医院肝胆外科,西安710068 [2]西安医科大学第一附属医院肝胆外科,西安710061 [3]西安医科大学第二附属医院普外科,西安710004

出　　处：《中国普外基础与临床杂志》2001年第6期373-374,共2页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　探讨晚期胰体尾部癌的药物缺血治疗效果。方法　解剖犬胰腺 ,结扎脾动脉近心端 ,远端插入化疗泵 ,注射尿素溶液并留置化疗泵 ,术中、术后从化疗泵注入 40 %尿素溶液 ( 1mg/kg体重 ) ,观察胰腺的病理及病理生理变化。结果　实验用 8只犬术后均存活 ,无严重并发症发生。缺血后胰腺各型细胞坏死 ,胰腺纤维化。结论　高浓度尿素溶液 ( 40 % )缺血治疗安全 ,效果明显 ,有可能成为治疗晚期胰体尾部癌的一种方法。Objective To investigate the effec t of ischemia on the treatment of advanced body and tail carcinoma of pancreas. Methods In operation the proximal spleen arter y was ligated, a chemotherapy pump was installed to connect the distal spleenic artery and urea solution (40%) was injected through the device during and after operation. The pathology and pathophysiology change in dogs w ere observed. Results All the eight dogs studied were aliv e after operation, no serious complication appeared, pancreatic cells were repl aced by fibrosis. Conclusion Infusion of 40% ur ea solution is a safe and effective ischemic method, it can lead to all sorts of pancreatic cell necrosis and fibrosis. It may be a good madality in the treatm ent of advanced pancreatic carcinoma.

关 键 词：动物模型 胰腺左叶缺血 病理 胰体尾部癌 尿素溶液 

分 类 号：R735.9[医药卫生—肿瘤]