高强度体外聚焦超声热疗治疗晚期胰腺癌近期疗效观察  

A Clinical Study on High Intensity Focused Ultrasound in Treating Patients with Advanced Pancreatic Carcinoma

作　　者：谢德荣[1] 姚波 陈积圣[3] 向燕群[4] 腾虹[4] 陈岱佳[4] 谢雪霞[4] 

机构地区：[1]中山医科大学孙逸仙纪念医院肿瘤,广东广州510120 [2]柳州铁路中心医院肿瘤科,广西柳州545007 [3]中山医科大学孙逸仙纪念医院外科,广东广州510120 [4]中山医科大学孙逸仙纪念医院肿瘤科,广东广州510120

出　　处：《肿瘤防治杂志》2001年第5期510-512,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :初步探讨高强度体外聚焦超声 (highintensityfocusedultrasound ,HIFU)热疗治疗晚期胰腺癌的疗效及安全性。方法 :13例晚期胰腺癌共接受 91次 (平均 7次 )HIFU治疗、其中 4例同时应用小剂量5 FU单药化疗。结果 :CR 2例、PR 4例 ,有效率 4 6 2 % ;临床受益反应率 (clinicalbenefitresponse ,CBR)高达 92 3% ;中位生存期 7 0个月 ;除 1例HIFU治疗后 5个月出现阻塞性黄疸外 ,未见其他副作用。结论 :HIFU治疗晚期胰腺癌能取得一定的疗效 ,治疗安全性高 ,值得临床进一步观察研究。Objective To observe the therapeutic and side effects of hight intensity focused ultrasound(HIFU)in treating patients with advanced pancretic carcinoma.Methods Thirteen patients with advanced pancreatic carcinoma received 91(average 7)times of HIFU therapy,4 cases of them combimed low dose 5 FU chemotherapy.Results 2 cases acquired CR and 4 PR,The response rate was 46 2%.The clinical benefit response(CBR)was 92 3% and the median survival was 7 0 months.There were few toxicities except one case having obstruct jaundice after 5 months later of HIFU therapy.Conclusions The preliminary results show that HIFU has a high efficacy and quite safety for advanced pancreatic carcinoma,it is worthy of futher clinical trail.

关 键 词：高强度体外聚焦超声 超声治疗 热疗 胰腺癌 

分 类 号：R735.9[医药卫生—肿瘤]