反流性食管炎患者胃底压力改变对食管运动功能的影响  

THE INFLUENCE OF PRESSURE CHANGES IN GASTRIC FUNDUS IN REFLUX ESOPHAGITIS TO MOTOR FUNCTION OF THE ESOPHAGUS

作　　者：于凤海[1] 李兆申[1] 许国铭[1] 邹多武[1] 尹宁[1] 

机构地区：[1]第二军医大学长海医院,上海上海东方肝胆外科医院200433

出　　处：《解放军医学杂志》2001年第10期724-726,共3页Medical Journal of Chinese People's Liberation Army

基　　金：上海市卫生系统百人计划科学基金 (编号 98BR0 2 6 );上海市青年科技启明星计划 (编号 99QB14 0 45 )资助课题

摘　　要：为了解反流性食管炎 (RE)患者胃底压力改变对下食管括约肌 (LES)和食管体下部运动功能的影响 ,采用自行设计的胃食管一体式导管 ,在不断增加胃底压力时 ,同步测量 8名健康志愿者和 13例RE患者的LES压力改变与食管体下部运动功能的改变。结果发现 ,RE组在空腹时和胃气囊充气后的LES压力、食管体下部运动功能显著低于正常组。RE组在胃底膨胀后有LES持续松弛、频发和持续时间过长的一过性下食管括约肌松弛 (TLESR)。提示RE是由多种因素促成的上消化道动力障碍性疾病 ,其LES的基础压力降低、食管体下部运动功能减弱和胃底膨胀后LES持续松弛。To investigate the influence of pressures change in gastric fundus in patients with reflux esophagitis (RE) to lower esophageal sphincter (LES) and motor function of lower esophagus. With gastro esophageal manometric catheter designed by the authors,the LESP and function of lower esophagus were synchronously measured,while the pressure in the gastric fundus was continuously increased, in 13 patients with RE and 8 healthy volunteers. The results showed that LESP and lower esophagus motor function of the RE group was significantly lower than that of the healthy group when the stomach was empty or when the pressure in the gastric fundus was increased.Whereas in the RE group, LES showed continuous relaxation,and frequent and transient lower esophageal sphincter relaxation (TLESR) were observed. It suggested that RE is an upper digestive tract motor disorder disease caused by various factors,the main mechanisms underlying RE are lower basic LES pressure and lower esophagus motor function. The LES showed continuous relaxafion and frequent and transient TLESR when the stomach is inflated.

关 键 词：胃底压力 食管胃接合处 食管活动障碍 反流性食管炎 

分 类 号：R571[医药卫生—消化系统]