EFP方案治疗进展期胃癌48例近期疗效观察  

EFP regimen combination chemotherapy in the treatment of advanced gastric cancer.

作　　者：向玉琴 赵冰 王勇慧 

机构地区：[1]陕西省肿瘤医院,西安710061

出　　处：《陕西肿瘤医学》2001年第3期169-170,183,共3页ShanXi Oncology Medicine

摘　　要：目的　观察EFP方案治疗进展期胃癌的近期疗效和患者的耐受性 ,寻找进展期胃癌有效的治疗方案。方法　对 48例进展期胃癌病人用EFP方案治疗。Vp16 10 0mg静滴第 1- 5天 ;FUDR5 0 0mg持续 12小时滴注 ,第 1- 5天 ;CBP15 0mg静滴 ,第 1- 3天 ;2 8天为一疗程 ,连用 2个疗程。结果　总有效率(CR +PR)为 6 2 5 % (30 / 48) ,完全缓解 (CR)为 12 5 % (6 / 48) ,部分缓解 (PR)为 5 0 % (2 4/ 48) ,稳定 (NC)为2 7% (13/ 48) ,进展 (PD)为 16 7% (8/ 48)。毒副作用为骨髓抑制和脱发。白细胞减少发生率Ⅰ Ⅱ5 8 3% ,Ⅲ Ⅳ 4 2 % ,血红蛋和血小板减少发生率分别为 33 34%和 2 9 2 6 %。脱发发生率为 6 2 5 % ,胃肠道反应发生率为 37 5 % ,其它副反应少见。结论　EFP方案治疗近展期胃癌疗效肯定 ,毒副反应可耐受 ,适用年龄偏大 ,体质较弱 ,既往治疗失败者。Objective To evaluate the combinated chemotherapy efficacy and toxicity of EFP regimen on advanced gastric cancer and search efficacious saved plan.Methods All the 48 patients were treated with EFP regimen. Therapy Vp16 60mg/m2 iv, from day 1 to day 5; FUDR 200mg/m2 continue 12h iv, from day 1 to day 5; CBP 70mg/m2 iv from day 1 to day 3; The treatment was repeated in 28 days.Results The overall response rate was 62.5%, complete response rate was 12.5%, partial response rate was 50%, no response rate was 27%, progression response rate was 16.7%. Toxicities were mainly myelosuppression and baldness. Grade Ⅰ-Ⅱ and Ⅲ-Ⅳ leukocytopenia (58.3% and 4.2%), thrombocytopenia (29.26%), anemia(33.34%), baldness (62.5%), gastrointestinal reactions(37.5%).Conclusion The EFP regimen is a better method for treatment of advanced gastric cancer.

关 键 词：胃肿瘤 依托泊苷 卡铂 氟脲脱氧核苷 药物疗法 疗效研究 

分 类 号：R735.2[医药卫生—肿瘤]