5-Fu与IFNα-2b联合治疗晚期大肠癌的肿瘤反应率和毒性:6个随机对照临床试验的Meta分析  

Tumor Response Rate and Toxicity of Fluorouracil with or Without Interferon Alpha-2b in Patients with Advanced Colorectal Cancer:A Meta-analysis of 6 Randomized Trials

作　　者：邹鸿志[1] 郁宝铭[1] 黎才海[2] 舒味冰[2] 赵任[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,200025 [2]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2001年第5期452-454,458,共4页The Practical Journal of Cancer

摘　　要：目的　评价IFNα 2b对 5 Fu(或 5 Fu +FA )治疗晚期大肠癌的肿瘤反应率和毒性的颖响。方法　共检索出符合入选标准的 6个随机对照临床试验 ,采用固定效应模型和随机效应模型对 82 6例患者的肿瘤反应率和毒性资料进行Meta分析。结果5 Fu(或 5 Fu +FA ) +IFNα 2b治疗的晚期大肠癌患者的肿瘤反应率较 5 Fu(或 5 Fu +FA )治疗者低 [2 0 .9%∶2 9.7% ,OR =0 .6 6 ,95 %可信限 (CI)为 0 .48～ 0 .91,P =0 .0 1] ;毒性分析表明 ,IFNα 2b加重 5 Fu(或 5 Fu +FA )引起Ⅲ、Ⅳ级血液毒性 (P <0 .0 1)和发热 (P =0 .0 4)的发生。结论　IFNα 2b不仅降低了 5 Fu(或 5 Fu ++FA)治疗晚期大肠癌的疗效 ,而且加重毒性 。Objective To evaluate tumor response rate and toxicity of fluorouracil(5 Fu) with or without interferon alpha 2b(IFNα 2b) in patients with advanced colorectal cancer.Methods Data of 826 patients in 6 randomized trials were meta analyzed with fixed effect model or random effect model.Results Tumor response rate was significantly lower in patients assigned to 5 Fu(5 FU+FA) and IFNα 2b than in those assigned to 5 Fu(5 FU+FA)(20.9% vs 29.7%,OR=0.66,95%CI,0.48～0.91, P =0.01).Grade 3 or 4 hematologic toxicity( P =0.001)and fever( P =0.04) was all more frequent in patients assigned to 5 Fu and IFNα 2b.Conclusion IFNα 2b significantly decreased efficacy of 5 Fu in advanced colorectal cancer and worsened it's toxicity,so it should not be recommended for routine use.

关 键 词：晚期大肠癌 氟脲嘧啶 干扰素 META分析 亚叶酸 

分 类 号：R735.34[医药卫生—肿瘤] R730.53[医药卫生—临床医学]