化疗和胸腺肽对恶性血液病患者免疫活性细胞的影响  

Thymopeptides Enhance T Lymphocyte Subset and NK Cell Activity in Malignant Hemopathic Patients

作　　者：陆紫敏[1] 顾凤英[1] 申远[1] 吴金莺[1] 

机构地区：[1]上海同济大学附属同济医院血液内科,200065

出　　处：《实用癌症杂志》2001年第5期529-531,共3页The Practical Journal of Cancer

摘　　要：目的　观察恶性血液病患者化疗前后外周血T细胞亚群及NK细胞活性 ,探讨胸腺肽对提高机体免疫功能的作用。方法　应用单克隆抗体和流式细胞仪检测化疗加胸腺肽治疗组 (A组 )和单纯化疗组 (B组 )恶性血液病患者化疗前后外周血T细胞亚群及NK细胞活性 ,并与对照组进行比较。结果　化疗前恶性血液病患者各项免疫活性细胞表达均低于对照组 ;治疗后A组的NK细胞活性明显高于B组 ,A组治疗后CD+ 3 、CD+ 4、CD+ 4/CD+ 8及NK细胞活性明显高于治疗前。结论　恶性血液病患者T细胞亚群、NK细胞活性受到明显抑制 ,胸腺肽能明显增强恶性血液病患者的细胞免疫功能 ,尤其是对NK细胞 ,它是Objective To test peripheral blood T cell and NK cell activity before and after chemical therapy in malignant hemopathic patient and observe effects of thymopeptides(TP) in improving the cell immunity function.Methods Malignat hemopathic patients were randomly and equally divided to chemotherapy group(B) and chemotherapy in combination with TP group(A).The T cell subsets and NK cell activity were determined by monoclonal antibody and flow cytometry(FCM) analysis the data were compared with that in the controls with benign diseases.Result Before treatment,the immune indeses of malignant hemopathic patient were lower than those of the controls.After treatment,the NK cell activity in A group significantly greater than that of B group.the peripheral blood of CD 3 +?CD 4 +?CD 4 +/CD 8 +and NK cell activity after treatment were significatly greater than before treatment.Conclusion The T cell subsets and NK cell activity are inhibited in malignant hemopathic patients.The TP can significantly improve the cell immunity function of malignat hempopathic patient,in particular,for NK cell,it is a highly effective biological response regulator,without any known side effect.

关 键 词：恶性血液病 免疫活性细胞 胸腺肽 白血病 淋巴瘤 骨髓瘤 治疗 

分 类 号：R733[医药卫生—肿瘤] R730.53[医药卫生—临床医学]