早期乳腺癌保留乳房和切除乳房的疗效观察  

Conservative surgery and modified radical mastec tomy for early stage breast cancer

作　　者：袁时芳[1] 王岭[1] 宁莫凡[1] 黄育勉[1] 

机构地区：[1]第四军医大学西京医院血管内分泌外科,西安710033

出　　处：《临床外科杂志》2001年第6期366-368,共3页Journal of Clinical Surgery

摘　　要：目的　评价早期乳腺癌保留乳房和切除乳房两种治疗方法的疗效。方法　 14 8例早期乳腺癌患者分保留乳房组 (保乳组 ,n =46 )和切除乳房组 (切乳组 ,n =10 2 )。前者行乳房的局部切除加腋淋巴结清扫 ,后者行乳房改良根治术。结果　 139例患者获得随访 ,随访期 3～ 13年。两组 3年、5年、10年的生存率分别为 10 0 %、87.88%、73.6 8%和 10 0 %、85 .92 %、75 .0 0 % ,局部复发率分别为 6 .98%、9.0 9%、5 .2 6 %和 7.2 9%、8.45 %、7.5 0 % ,远处转移率分别为 2 .33%、12 .12 %、10 .5 3%和 3.13%、12 .6 8%、12 .5 0 %。两组各指标差异无显著 (P >0 .0 5 ) ;而保留乳房组手术创伤小 ,乳房美观满意率 81.4% ,与后者相比差异有显著性 (P <0 .0 1)。结论　与乳房的改良根治术相比 ,乳房的局部切除腋淋巴结清扫加根治性放疗对于早期乳腺癌疗效可靠 ,生活质量提高 ,是一种安全、有效的方法 ,但应有严格适应证。Objective To investigate and compare the clinical value of breast conservative surgery and modified radical mastectomy for early stage breast cancer retrospectively.Methods Of 148 total cases, 46 cases of breast cancer were treated with breast conservative surgery (BCS group) and 102 cases were treated with modified radical mastectomy (MRM group).Results Of 148 total cases, 139 cases have been followed up from 3 years to 13 years.The 3-, 5-and 10-Year survival rate of those two group were 100%?87.88%?73.68% and 100%?85.92%? 75.00%, The local recurrence rate were 6.98%? 9.09%? 5.26% and 7.29%?8.45%?7.50%, distant metastasis rate were 2.33%?12.12%?10.53% and 3.13%?12.68%?12.50% , respectively (P>0.05). The satisfied rate of cosmetic results of the former breast were 81.4%, compared with the latter (P<0.01) .Conclusion Compared with modified radical mastectomy , breast conservative surgery for early stage breast cancer , which could guarantee the therapeutic effect of cancer and enhance the quality of life, was a safe and effective method, but its results depend on strict adherence to indication of treatment.

关 键 词：乳腺癌 保守性手术 乳房切除 改良根治术 

分 类 号：R737.9[医药卫生—肿瘤]