白细胞介素-1受体拮抗剂治疗激光角膜灼伤的图像分析  

The Image Analysis of Laser-burn Corneal Lesions After Interleukin-1 Receptor Antagonist Treatment

作　　者：张杰[1] 单清[1] 任华[1] 王登龙[1] 姜严明[1] 钱焕文[1] 

机构地区：[1]军事医学科学院放射医学研究所,北京市100850

出　　处：《中国激光医学杂志》2001年第4期230-233,共4页Chinese Journal of Laser Medicine & Surgery

基　　金：全军"九五"指令性科研课题 (96L0 2 9)

摘　　要：目的　应用图像分析法观察白细胞介素 1受体拮抗剂 (Interleukin 1receptorantagonist,IL 1ra)对激光角膜灼伤的治疗作用。方法　用CO2 激光造成日本大耳白兔角膜灼伤斑。将实验兔分为 5个实验组 ,每组 5只 ,分别为灼伤组、IL 1ra 2 5 μg/ml治疗组、5 0 μg/ml治疗组、10 0 μg/ml治疗组和地塞米松 (dexamethasone,DM)治疗对照组。分别于角膜灼伤后 1、2、3周取角膜做图像分析。结果　图像分析结果表明 ,应用IL 1ra滴眼治疗有利于角膜灼伤斑面积的缩小和角膜透明度的恢复。结论　ILObjective To observe the effect of Interleukin 1 receptor antagonist (IL 1ra) on laser induced cornea burns by applying image analysis. Methods The corneas of white rabbits were exposed to CO 2 laser. The animals were divided into five groups, each containing 5 animals. One group was the burn control. Another three groups were treated with IL 1ra 25 μg/ml, 50 μg/ml and 100 μg/ml respectively. The last group was treated with 1 mg/ml dexamethason (DM). Image analysis was performed 1, 2 and 3 weeks after laser corneal burn. Optical density (OD) and integral optical density (IOD) were measured for analysis. Results Both OD and IOD show that the area of IL 1ra treated groups was significantly reduced compared to the DM treated group and the control group, which indicates that IL 1ra is beneficial to reduce the area of the corneal burns and to improve the recovery of corneal transparence. Conclusion IL 1ra has significant therapeutic effect on corneal burn induced by laser.

关 键 词：白细胞介素-1受体拮抗剂 角膜灼伤 激光 图像分析 

分 类 号：R772.2[医药卫生—眼科]