复杂易位遗传效应的探讨——附一例罕见复杂易位核型  

A Study of Genetic Effects of Complex Chromosomal Translocation

作　　者：刘京昇[1] 杜可明[1] 宗传龙[1] 李效良[1] 郭淼[1] 

机构地区：[1]泰山医学院生物学教研室,山东泰安271000

出　　处：《遗传》2001年第6期515-517,共3页Hereditas（Beijing)

摘　　要：本文报道一例罕见复杂易位核型 :46 ,XX ,t(1;14;10 )。并结合以往资料 ,探讨和分析复杂易位和一般平衡易位对表型及生育的遗传效应。结果显示 ,一般易位导致智能低下和多发畸形的频率各为 3.5 7%;复杂易位所致智能低下频率为 2 1.73%,多发畸形的频率为 17.39%。提示复杂易位所致智能低下和畸形频率明显高于一般易位。In this paper,we report a rare karyotype of complex translocation:46,XX,t(1;14;10).Based on sufficient published data,we discussed and analyzed the genetic effect of complex translocation and general balanced translocation on phenotype and fertilization.The results show that general balanced translocation caused 3.57% low intelligence and multi-deformation while complex translocation caused 21.73% low intelligence and 17.39% multi-deformation respectively .These results sugget that there is a higher incedence of low intelligence and multi-deformation caused by complex translocation than that caused by general balanced translocation.

关 键 词：复杂易位 遗传效应 表型 核型 

分 类 号：Q343.22[生物学—遗传学]