p27kip1在胃癌中的表达和意义  

p27kip1 Expression and its Biological Significance in Gastric Cancer

作　　者：李宏武[1] 毕海波[1] 张世浦[1] 

机构地区：[1]沈阳医学院附属第二医院普外科,沈阳110002

出　　处：《沈阳医学院学报》2001年第2期72-74,89,共4页Journal of Shenyang Medical College

摘　　要：目的　探讨 p2 7kip1 (细胞周期素依赖性激酶抑制因子 )在胃癌中表达及其与胃癌临床病理学特征的关系。方法　采用免疫组织化学方法检测 p2 7kip1在 60例胃癌组织原发灶和淋巴结转移灶中的表达。结果　p2 7kip1在胃癌的阳性表达率为 43 33% ( 2 6/60 ) ,阳性细胞定位于细胞浆 ,在高分化及Ⅰ ,Ⅱ期胃癌高表达 (P <0 0 5 ) ,且与淋巴结转移密切相关 (P <0 0 1 )。结论　p2 7kip1表达与胃癌组织分化程度、淋巴结转换呈负相关 ;p2 7kip1表达对估计胃癌预后有一定意义。Objective To evaluate the relationship between p27kip1 expression and biological behavior, lymph node (LN) metastasis of gastric cancer. Methods The protein expression of p27kip1 was investigated by immunohistochemistry method (Streptavidin-Peroxidase, S-P) in 60 cases of formalin-fixed, paraffin-embedded primary and metastatic foci of gastric cancer. Results The expression rate of p27kip1 was 43.33%(26/60), Its protein was located mainly in the cytoplasm. There was high expression of p27kip1 in differentiated tumor and Ⅰ,Ⅱ stage tumor. p27kip1 expression related to PTNM stage and LN metastasis. Conclusion p27kip1 expression and tissue type and lymph node metastasis of gastric cancer was correlated negatively. p27kip1 expression may have some value in evaluating prognosis of gastric cancer

关 键 词：胃癌 细胞周期素依赖性激酶抑制因子 免疫组织化学 P27KIP1 CDK 

分 类 号：R735.2[医药卫生—肿瘤]