衰老大鼠的某些脑区组织中游离氨基酸水平的改变  

Changes of Free Amino Acid Levels in Different Brain Regions of Aging Rats

作　　者：殷伟平[1] 蒋滢[1] 蒋菊香[2] 王尉平[2] 

机构地区：[1]苏州大学医学院,江苏苏州215007 [2]苏州大学生命科学学院

出　　处：《氨基酸和生物资源》2001年第4期36-38,共3页Amino Acids & Biotic Resources

摘　　要：使用D 半乳糖建立衰老大鼠模型组与同龄、同饲的正常对照组大鼠的某些脑区游离氨基酸 (FAA)水平的比较发现 :( 1 )衰老模型组的海马、纹状体以及皮层等脑区中谷氨酸 (Glu)、天门冬氨酸 (Asp)水平明显降低 ;( 2 )γ 氨基丁酸 (GABA)水平在衰老模型组大鼠的海马 ,纹状体以及小脑等脑区中明显升高 ;( 3)衰老模型组的皮层、小脑、海马、纹状体等脑区的牛磺酸 (Tau)水平明显下降。Wistar's rats were injected with D-galactose to construct a aging animal model. Then the free amino acid levels in certain brain regions of the aging model were compared with control group. The results showed: (1)Glu and Asp levels of hippocampus(hipp.), striatum(str.) and cortex(cort.) decreased obviously in aging model; (2)GABA level of hippocampus, striatum and cerebellum(cerebell.) regions increased apparently in aging model; (3)taurine level of cerebellum, hippocampus, striatum and cortex decreased obviously in aging model group.

关 键 词：衰老 脑区 游离氨基酸 大鼠 

分 类 号：R339.38[医药卫生—人体生理学] Q419[医药卫生—基础医学]