nm23在胚胎组织和肺癌组织中表达的意义  

The significance of nm23 gene expression in embryonic tissues and lung cancer tissues

作　　者：谢作煊[1] 刘凯珊[1] 何文芳 

机构地区：[1]暨南大学医学院病理解剖学教研室,广州510630

出　　处：《中国肺癌杂志》2001年第6期448-451,共4页Chinese Journal of Lung Cancer

摘　　要：目的　探讨nm2 3 H1基因的表达与胚胎组织发育分化的关系和在肺癌组织中表达的意义。方法　对SD大鼠和人的胚胎组织 ,以及人肺癌组织进行nm2 3蛋白 (NM2 3 H1)免疫组化检测。结果　NM2 3 H1的积聚与胚胎发育期间各种上皮组织的分化和器官形成相一致 ,正常胚胎组织要发育至一定阶段 ,具有一定空间构型 (器官结构 )时才有较稳定的NM2 3 H1积聚。在 49例肺癌原发病灶中 ,NM2 3 H1阳性率 3 4 .7% ,其中鳞癌的阳性率 2 7.3 % ,腺癌的阳性率 5 0 .0 % ,5例未分化大细胞癌均阴性。 2 7例肺门淋巴结转移癌灶的NM2 3 H1阳性率 (2 2 .2 % )与原发瘤灶中的阳性率 (3 4 .7% )比较差异无显著性 (P >0 .0 5 )。在肺癌原发病灶中 ,NM2 3 H1阳性与阴性二组间淋巴结转移发生率的差异亦无显著性 (P >0 .0 5 )。结论　NM2 3 H1在胚胎组织和肺癌组织中的积聚与胚胎组织和肺癌组织器官样结构的分化有密切关系 ,NM2 3 H1可能对维持稳定的上皮组织结构起着重要的调节作用。NM2 3 H1似乎不能直接抑制肺癌细胞的转移。Objective To clarify the relationship between nm23 H1 gene and differentiation of embryonic tissues and the significance of its expression in pulmonary carcinoma. Methods nm23 H1 protein (NM23 H1) was detected in the embryonic tissues of SD rats and human being, as well as in human lung cancer tissues, by immunohistochemistry method. Results Only embryonic tissues with definite configuration (organ structure) expressed NM23 H1 constantly. Positive rate of NM23 H1 was 34.7% in 49 cases of human lung cancer tissues, and 27.3% in squamous cell carcinoma, 50.0% in adenocarcinoma. The positive rate of NM23 H1 was 22.2% in 27 cases of hilar lymph node metastatic foci, and 34.8% in primary tumour foci (P>0.05). There was no significant difference of lymphatic metastatic rates between NM23 H1 positive and negative primary tumors. Conclusion There is positive correlation between accumulation of NM23 H1 and differentiation of embryonic tissues and lung carcinoma. NM23 H1 may play an important role in maintaining a stable epithelial structure. It doesn't show that NM23 H1 can directly inhibit the metastasis of lung cancer cells.

关 键 词：胚胎组织 肺肿瘤 分化 NM23蛋白 肿瘤转移 

分 类 号：R734.2[医药卫生—肿瘤]