不同介入方法治疗兔VX-2肝肿瘤的实验研究  

An Experimental Study of Different Interventional Methods on theVX-2 Tumor in the Rabbits Liver Bearing

作　　者：刘嵘[1] 王建华[1] 周康荣[1] 颜志平[1] 钱晟[1] 邵国良[1] 罗剑均[1] 

机构地区：[1]复旦大学医学院附属中山医院放射科,上海200032

出　　处：《实用放射学杂志》2001年第8期561-564,共4页Journal of Practical Radiology

基　　金："九五"国家医学科技攻关项目专题号 :96 -90 7- 0 3 - 0 1

摘　　要：目的　评价三种不同介入方法治疗兔VX -2肝肿瘤的疗效和副反应。方法　 2 4只实验兔分为三组 ,单纯灌注化疗组 7只、化疗性栓塞组 8只、生理盐水治疗组 9只 ,实验均采用经兔股动脉肝动脉插管方法。分别于介入术前、术后 1周、术后 2周行兔肝肿瘤螺旋CT扫描 ,测量肿瘤大小并观察肿瘤变化情况 ,计算不同介入方法治疗后肿瘤的增长率。 2周后行兔肝脏病理检查 ,比较肿瘤生长、肺转移和周围正常肝组织的情况。结果　单纯灌注化疗组、化疗性栓塞组、生理盐水对照组术后 1周平均肿瘤增长率分别为 90 .88%、75 .45 %、3 5 0 .96%。术后 2周平均肿瘤增长率分别为 2 83 .49%、2 3 7.99%、845 .43 %。 2周后化疗栓塞组兔肿瘤周围炎性细胞浸润和周围肝组织缺血情况明显高于其余 2组 ,肝内肿瘤播散结节和肺转移结节明显少于其余 2组 ,统计学比较有明显差异 (Ρ <0 .0 5 )。结论　在肝癌的介入治疗中 ,单纯化疗有一定的疗效 ,带化疗药物的碘油等栓塞剂的使用可进一步提高疗效。碘油等栓塞剂对正常肝组织有损害作用 ,应避免或减少其进入正常肝组织。Objective To evaluate the curative effect and side effects of different interventional methods on the rabbits bearing VX-2 hepatic tumor.Methods 24 rabbits with the VX-2 hepatic tumor were divided into three groups,1:transcatheter artery infusion(TAI) with antitumor drugs(n=7),2:transcatheter artery embolization(TAE)used lipiodol plus antitumor drugs(n=8),3:0.9% physiological saline therapy(n=9).Spiral CT scan of the hepatic tumors was performed pre-therapy,one and two weeks after interventional therapy.The size and change of hepatic tumors were obtained and the growth rate of tumors were calculated to evaluate the therapeutic effevtiveness.The pathological examinations were performed 2 weeks after interventional therapy.The growth of the tumors,lung metastases,and the normal hepatic tissues around the tumor were compared.Results The growth rate of tumors of the 1,2,3 groups were 90.88%,75.45%,350.96% respectively one week after interventional therapy,and the growth rate of tumors two weeks after therapy were 283.40%,237.99%,845.43% respectively.The changes of inflammatory cells infiltration,ischemia of the normal hepatic tissue were significantly higher in the TAE group than those of other 2 groups,and the number of dissemination nodules in the liver,metastatic nodules in the lung were significantly less than those of other 2 groups.The different between TAE group and other 2 groups was statistically significant(Ρ<0.05.Conclusion TAI with antitumor drugs has certain effect in treatment of liver cancer,TAE using lipiodol plus antitumor drugs can further improve the antitumor effect.The embolic materials as lipiodol can damage the normal tissue.These embolic materials should be avoid or reduce to enter the normal hepatic tissue in the treatment of the liver cancer.

关 键 词：兔 动物模型 肝肿瘤 介入治疗 疗效 副反应 

分 类 号：R735.7[医药卫生—肿瘤] R73-36[医药卫生—临床医学]