肝硬化门脉高压大鼠胃粘膜屏障功能的观察  

Observation on barrier capability of portal hypertensire gastric mucosa

作　　者：薛龙[1] 周东风[1] 

机构地区：[1]青岛市市立医院,山东青岛266011

出　　处：《山东医药》2001年第22期20-21,共2页Shandong Medical Journal

摘　　要：建立两组门脉高压症 (PH)动物模型 ,并与对照组 (SO组 )比较 ,以观察胃粘膜屏障功能的改变。结果显示 ,与 SO组比较 ,门静脉狭窄组 (PVS组 )大鼠内脏血流量明显增加 (Ρ<0 .0 0 1) ,胃粘膜处于缺血状态 ,胃壁结合粘液 (GP)显著下降 (P<0 .0 1) ;肝硬化门脉高压症组 (PL组 )较 PVS组降低更明显 (P<0 .0 5 ) ;三组间胃基础泌酸量 (BAS)无差异。 PVS组、 PL组大鼠 H+ 返渗量 (H+ BD)均明显高于 SO组 (P<0 .0 0 1) ,表明 PVS大鼠胃粘膜屏障功能破坏严重 ,尤以 PL大鼠为甚 ;门脉高压胃病 (PHG)与胃粘膜屏障功能严重减弱有关 。Two models of portal hypertensive rats with cirrhosis and extrahepatic portal vein stenosis respectively were designed ,and the abnormal barrier capability of these two models were observed. Result showed that the splenchic blood folw of the portal hypertensive ratsincreases,as compared with the comtrol group(P<0.01),but actually gastric mucosa was under the comdition of ischia. Mucus of grastric wall(Glycoprotein,GP)decrease,as compared with the normal control(P<0.01),and more serious decreases occur in cirrhotic poratl hypertensive rats. There was no significant difference about the amount of the basal acid sccrction among the three groups,but the amount of H + back diffusion was obviously increased,as compared with the normal control group(P<0.01). The amount of H +BD of cirrhotic portal hypertensive rats is the highest aong these three groups. This suggests the barrier capability of gastric mucose with portal hypertension is lower than that of the noral contral group and still lower whith cirrhotic portal hypertensiverats. The poratl hypertensive gastropathy is associatcd with the lower dcfcnsc capability not caused by “hyperacid”. The condition of liver function contributes to the changes of barrier capability of gastric mucosa.

关 键 词：肝硬化 门脉高夺 胃粘膜 屏障功能 

分 类 号：R575.21[医药卫生—消化系统]