直肠癌及其癌旁粘膜中维生素D受体表达的研究  

Expression of vitamin D receptor in rectal carcinoma and mucosa adjacent to carcinoma

作　　者：王少华[1] 唐伟军[1] 钟鸣[1] 陈锦先[1] 吴志勇[1] 王平治[1] 

机构地区：[1]上海第二医科大学附属仁济医院外科,200001

出　　处：《中华普通外科杂志》2001年第11期680-682,共3页Chinese Journal of General Surgery

摘　　要：目的　探讨直肠癌及其近旁粘膜组织中维生素D受体 (VDR)的表达。方法　采用免疫组化结合显微光度测量图像分析技术 ,对 2 1例直肠癌及其近旁粘膜中VDR表达与正常大肠粘膜比较。结果　直肠癌组织中VDR表达 ( 2 4± 0 7)显著低于正常大肠粘膜 ;癌旁 2cm粘膜中VDR表达 ( 4 6± 0 5 )介于癌组织与正常粘膜 ( 6 0± 0 6)之间 ,与 2者差异均有显著意义。癌组织中VDR的表达在不同的年龄、性别、Dukes分期、组织学分型、肿瘤生长方式、浸润深度之间差异无显著意义 ;VDR表达与癌组织分化程度之间有显著联系 ,高、中、低分化 3组VDR表达依次降低且差异有显著意义 (P <0 0 5 )。其中癌旁 2cm粘膜DNA异倍体者占 5 7 1% ,增殖指数显著高于正常粘膜。结论　直肠癌及其近旁粘膜组织中VDR表达下降。癌旁 2cm粘膜具有向肿瘤转化的倾向。Objective To evaluate the expression of vitamin D receptor (VDR) in rectal cancer and mucosa adjacent to cancer. Methods The VDR expression of tumor tissue,mucos a 2cm apart from tumor and normal mucosa was detected by imunohistochemistry, mi crospectrophotometer and computer image analysis in 21 cases of rectal carcinoma . Results The VDR expression in rec tal tumor (2.4±0.7) significantly decreased compared to that of the norma l mucosa (6.0±0.6)(P<0.01). The VDR expression of mucosa 2 cm apart from tumor (4.6±0.5) was significantly different from both normal tissue and carcinoma (P<0.01). There was no significant correlation between VDR e xpression of carcinoma and the gender, age, histological classification, Dukes s tage, the way tumor grows and infiltration depth. A significant correlation was found between the VDR expression and differentiation grade of the carcinoma, wel l defferentiated carcinoma had the highest level of VDR expression. The incidenc e of heteroploid (57.1%) of the mucosa 2 cm apart from tumor was different from that of normal mucosa. Proliferation index of the adjacent mucosa was significa ntly higher than the normal mucosa. Conclusions The low expression of VDR is one of the reasons for the loss of re gulation from vitamin D on proliferation and differentiation of the rectal carci noma cells. The mucosa 2 cm apart from rectal carcinoma has a tendency to transf orm into malignancy.

关 键 词：直肠肿瘤 受体 骨化三醇 维生素D 直肠癌 

分 类 号：R735.37[医药卫生—肿瘤]