皮肤鳞状细胞癌中基质金属蛋白酶与C-myc表达的研究  

Expression of Matrix Metalloproteinases and C-myc in Cutaneous Squamous Cell Carcinoma

作　　者：王建力[1] 陈莉[2] 王桂兰[2] 

机构地区：[1]江苏省南通医学院附属医院皮肤科,226001 [2]南通医学院病理教研室

出　　处：《中华皮肤科杂志》2001年第6期432-434,共3页Chinese Journal of Dermatology

基　　金：江苏省科委课题(Bs99358)

摘　　要：目的研究68例皮肤鳞状细胞癌中基质金属蛋白酶MMP2、MMP9与癌基因C-myc表达的关系,及与癌分化程度的关系。方法应用免疫组化(LSAB)法检测石蜡包埋组织中MMP2、MMP9和C-myc表达。结果MMP2、MMP9定位于细胞浆中,分布于癌细胞及癌旁间质细胞中,特别见于肿瘤细胞与间质交界处,癌巢中心角化区未见MMP2和MMP9的表达。MMP2和MMP9随癌分化降低其表达增强。癌基因C-myc表达增强时,癌中MMP2和MMP9表达也增强。结论MMP2和MMP9的分泌是癌细胞和间质细胞的共同事件,但以癌细胞占优势,C-myc癌基因有可能促进癌细胞分泌更多MMP2和MMP9。Objective To investigate the expression of matrix metalloproteinases(MMP) related to oncogene C-myc and tumor differentiation of cutaneous squamous cell carcinoma (CSCC). Methods Expression of MMP2,MMP9 and C-myc was detected by immunohistochemistry in 68 paraffin embedded specimens of CSCC. Results Distribution of MMP2 and MMP9 was demonstrated within cytoplasm of tumor and stromal cells, especially for those cells at the interface of tumor and interstitial tissues. No expression of MMP2 and MMP9 was observed in the horny centers of tumor cell nests. Expression of MMP2 and MMP9 increased along with the decreasing of the differentiation of tumor tissue and the increasing of C-myc expression. Conclusions Expression of MMP2 and MMP9 might be a common event for both tumor and stromal cells but parenchymal tumor cells might predominate over the activation of MMP2 and MMP9. Oncogene C-myc protein might promote the secretion of MMP2 and MMP9 by tumor cells.

关 键 词：金属蛋白酶 C-MYC 皮肤肿瘤 皮肤鳞状细胞癌 

分 类 号：R739.5[医药卫生—肿瘤]