老年急性脑血管病患者细胞因子及其受体的研究  

The relationship between cytokines or their receptors and acute cerebrovascular disease in old patients

作　　者：何志义[1] 欧阳嶷[1] 张强[1] 范红杰[1] 房晓[1] 吕昌龙[2] 

机构地区：[1]中国医科大学第一临床学院神经内科,辽宁沈阳110001 [2]中国医科大学基础医学院免疫学教研室,辽宁沈阳110001

出　　处：《中华老年心脑血管病杂志》2001年第5期322-325,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：辽宁省自然科学基金 ( 9910 5 0 0 2 0 3)

摘　　要：目的　探讨老年急性脑血管病患者细胞因子及其受体的变化。方法　采用酶联免疫吸附试验测定 6 5例老年急性脑血管病患者血清可溶性白细胞介素 2受体 (sIL 2R)、可溶性白细胞介素 6受体 (sIL 6R)、可溶性细胞间粘附分子 1(sICAM 1)及转化生长因子 β1(TGF β1)的含量。另选 38名健康人作为对照。结果　老年急性脑血管病患者的血清sIL 2R为 (75 4± 2 0 3)U/ml,sIL 6R为 (5 8± 12 )mg/L ,sICAM 1为 (5 5 8± 2 11) μg/L ,比对照组均明显升高 ,而TGF β1[(2 2± 10 ) μg/L]含量明显减少。头颅CT显示病灶大小与血清sICAM 1含量呈显著正相关。 结论　血清sIL 2R、sIL 6R、sICAM 1及TGFObjective To investigate the effects of soluble interleukin 2 receptor(sIL 2R),soluble interleukin 6 receptor(sIL 6R),soluble intercellular adhesion molecule 1(sICAM 1)and transforming growth factor β 1(TGF β 1) on acute cerebrovascular disease in old patients.Method Levels of sIL 2R,sIL 6R,sICAM 1 and TGF β 1 in serum of 65 old patients with acute cerebrovascular disease and 38 controls were measured by ELISA method.Results Compared with the control group,the levels of sIL 2R [(754±203) U/ml],sIL 6R [(58±12) mg/L] and sICAM 1 [(558±211) μg/L] significantly increased,and the level of TGF β 1 [(22±10) μg/L] decreased in the serum of old patients with acute cerebrovascular disease.There was a significant correlation of serum sICAM 1 levels with the size of foci in CT scan.Conclusion The levels of sIL 2R,sIL 6R,sICAM 1 and TGF β 1 in serum might be the important parameters for clinical evaluation of acute cerebrovascular disease in old patients.

关 键 词：老年人 脑血管意外 白细胞介素类 细胞间粘着分子 转化生长因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]