人参茎叶皂苷对大鼠实验性坐骨神经损伤保护作用的研究  

Experimental study on protective effects of gensenosides on wistar rat nerve injury

作　　者：冯凯[1] 侯晓强[2] 

机构地区：[1]河北省唐山工人医院 [2]华北煤炭医学院附属开滦医院

出　　处：《华北煤炭医学院学报》2001年第5期543-544,共2页Journal of North China Coal Medical College

摘　　要：目的　探讨人参茎叶皂甙对周围神经损伤的保护作用。 2方法　以 Wistar大鼠坐骨神经捻挫为动物模型 ,用人参茎叶皂甙给大鼠灌胃 ,于周围神经损伤后不同时期检测感觉神经传导速度 ( SCV)及坐骨神经功能指数 ( SFI)。并进行形态计量学图像分析。3结果　周围神经损伤后 2周 SCV、SFI及有髓纤维的密度均优于对照组 ( P<0 .0 5 )。To observe protective effects of gensenosides(PGS) on peripheral nerves injury.Methods The wistar rat whose sciatic nerves were contused was used as animal model.The rat was gavaged with gensenosides.Sensorineural communicate velocity(SCV) and sciatic nerve functional index was detected in different stages after crush injury.Morphometric analysis was made to explore protective effect of gensenosides on peripheral nerve injury.Results Two weeksafter injury,SFI,SCV and myelinated fiber density were greater than control(P<0.05).Conclusion gensenosides.could improve regencration of myelinated fibers after Wistar rat sciatic nerves injury as well as recovery of function of nerve fibers.

关 键 词：感觉神经传导速度 坐骨神经功能指数 人参茎叶皂甙 周围神经损伤 

分 类 号：R745.42[医药卫生—神经病学与精神病学]