精神分裂症患者认知功能损害与阴阳性症状的关系  

The relationship of schizophrenic cognitive function impairment with positive and negative symptoms

作　　者：王锦霞[1] 南振国[1] 白京生[1] 及惠郁[1] 杨甫德[1] 王安文[1] 王健[1] 李尚明[1] 李娟[1] 王绍礼[1] 王向群[1] 

机构地区：[1]北京回龙观医院,100096

出　　处：《临床精神医学杂志》2001年第6期346-348,共3页Journal of Clinical Psychiatry

摘　　要：目的 :探讨精神分裂症认知功能损害与阴性、阳性症状的关系。　方法 :对 73例入组的患者随机给予利培酮、氯氮平治疗 12周 ,并于治疗前、后盲法评定 Wisconsin卡片分类测验 (WCST) ,Wechsler记忆测验 (WMS) ,阴性症状评定量表 (SANS)与阳性症状评定量表 (SAPS)。　结果 :治疗前精神分裂症患者的阴性症状、阳性症状均与认知功能有显著相关。主要与执行功能相关 ;注意障碍与记忆相关。治疗后 ,仅 SAPS中怪异行为得分与 WCST的持续反应数、持续错误数显著相关。　结论 :精神分裂症的认知功能损害是原发性的 ,并不是在阳性。Objective:To explore the relationship between cognitive function impairment and negative and positive symptoms in schizophrenic patients. Method:73 schizophrenic patients were treated randomly with risperidone or clozapine for 12 weeks.They were assessed with WCST,WMS,SANS and SAPS separately before and after 12 weeks treatment. Results:Both negative and positive symptoms before treatment were significantly correlated with cognitive symptoms.They were correlated mainly with executive function;Attention impairment was correlated with memory.After treatment,only bizarre behaviour of SAPS was correlated with perseverative respond and perseverant errors of WCST.Conclusion:Cognitive function impairment of schizophrenia is a primary symptom which is not based on negative and positive symptoms.

关 键 词：精神分裂症 认知功能 阴性症状 阳性症状 

分 类 号：R749.3[医药卫生—神经病学与精神病学]