分子疫苗防治老年性痴呆小鼠模型的研究进展  

Progress on Immunization with Amyloid-β in a Mouse Model of Alzheimer's Disease

作　　者：张薇[1] 华茜[2] 张岱[1] 赫荣乔[2] 

机构地区：[1]北京大学第六医院,北京100083 [2]中国科学院生物物理研究所视觉信息加工开放实验室,北京100101

出　　处：《生物化学与生物物理进展》2001年第6期781-782,共2页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展规划 (973规划 ) (G1 9990 540 0 7)~~

摘　　要：老年斑是老年性痴呆 (Alzheimer sdisease ,AD)的特征性病理改变 ,β 淀粉样 (β amyloid ,Aβ)是其主要成分 .将Aβ作为疫苗对动物进行免疫 ,有明显抑制转基因小鼠脑内Aβ的沉积 ,清除原有斑块的作用 ,从而减少异常Aβ沉积对认知功能的损害 .疫苗没有引起针对动物自身抗原的免疫反应 。amyloid(Aβ) is a predominant component of senile plaques, one central pathological hallmark of Alzheimers disease. Immunization with Aβ causes a marked reduction of Aβ burden and its associated pathologies in brain. A clearance of the preexisting plaques has been observed in transgenic mice, with an inhibition of lesion of cognitive functions. No signs of an immune mediated response could be detected to endogenous Aβ peptide of mice. The chronic inflammatory response resulted from the immunization itself has not obviously impaired functions of central nerve system.

关 键 词：Β-淀粉样 老年性痴呆 星形胶质细胞聚集 分子疫苗 防治 小鼠模型 

分 类 号：R749.16[医药卫生—神经病学与精神病学]