激光低损伤加热疗法的理论分析  

Theoretical Study on Low Invasive Laser Coagulation Method

作　　者：周建华[1] 刘登瀛[1] 徐建中[1] 

机构地区：[1]中国科学院工程热物理研究所,中国北京100080

出　　处：《激光生物学报》2001年第4期241-254,共14页Acta Laser Biology Sinica

基　　金：国家自然科学基金重点基金 (5 9736 130 );中国科学院"九五"基础性研究重大项目 (KJ95 1-B1- 70 4);国家重点基础研究发展规划项目资金 (G2 0 0 0 0 2 6 30 5 )

摘　　要：激光低损伤加热疗法将激光照射与表面冷却相结合 ,能实现只让病变组织细胞凝固 ,而体表健康组织则不受损伤。它是治疗靠近体表肿瘤的一种很有希望的方法。为了进一步认识这种治疗方法 ,本文提出了一个适用于激光低损伤加热疗法的数值计算模型 ,模拟了热疗过程中的光传输和热传递 ,得到组织内部的瞬态温度分布。在此基础上 ,详细讨论了散射系数、吸收系数、各向异性系数等光学参数 ,激光加热功率、照射半径、表面对流换热系数等热学参数 ,以及血液灌注率和新陈代谢等生理参数对这种低损伤加热疗法的影响。结果发现 ,只要通过适当调节吸收系数、散射系数和照射功率等参数就可实现对加热区域位置和范围的控制。Laser irradiation in conjunction with surface cooling,called Low Invasive Laser Coagulation (LILC),provides a promising therapy for superficial cancer,which can cauterize the inner tissue with the tissue surface undamaged.In order to provide a further insight into this therapy,this paper developed a transient finite difference numerical model of the LILC method. It was then used to simulate the light propagation and heat transfer inside the tissue. The effects of various optical coefficients (such as scattering and absorption coefficients,anisotropy parameter,etc.) and thermophysical properties (such as surface convective coefficient,etc.) and physiological coefficients (such as blood perfusion rate and metabolic heat generation,etc.) on the thermal behavior of the LILC method were discussed in detail. The results show that the size and location of cauterized tissue under the skin can be bontrolled by properly adjusting the absorption and scattering coefficients and irradiation power and so on.

关 键 词：激光低损伤加热疗法 生物组织 辐射传输方程 七流模型 生物传热方程 

分 类 号：R454.2[医药卫生—治疗学] Q631[医药卫生—临床医学]