中枢精氨酸加压素在大鼠促肾上腺皮质激素释放激素引起发热机制中的作用(英文)  

The role of central arginine vasopressin in corticotropin releasing hormone-induced fever in rats

作　　者：王华东[1] 王彦平[1] 胡巢凤[1] 戚仁斌[1] 严玉霞[2] 陆大祥[1] 李楚杰[1] 

机构地区：[1]暨南大学医学院病理生理教研室,广州510632 [2]暨南大学医学院生化教研室,广州510632

出　　处：《生理学报》2001年第6期465-468,共4页Acta Physiologica Sinica

基　　金：ThisstudywassupportedbytheNationalNaturalScienceFoundationofChina (No 3970 0 0 5 5 )

摘　　要：实验对大鼠进行第三脑室和脑腹中隔区插管 ,用数字体温计测量大鼠的结肠温度 ,用放射免疫分析法测定脑中隔区精氨酸加压素 (argininevasopressin ,AVP)含量 ,观察脑中隔区AVP在大鼠促肾上腺皮质激素释放激素(corticotrophinreleasinghormone ,CRH)性发热机制中的作用。结果发现 :脑室注射CRH (5 .0 μg)引起大鼠结肠温度明显升高 ,同时明显增高脑中隔区AVP的含量。脑腹中隔区注射AVPV1受体拮抗剂本身并不导致大鼠结肠温度明显改变 ,但能显著增强脑室注射CRH引起的发热反应。而且 ,腹中隔区注射AVP显著抑制大鼠CRH性发热。结果提示 :发热时CRH是引起脑腹中隔区AVP释放的因素之一 ,脑腹中隔区内源性AVP抑制中枢注射CRH引起的体温升高。The purpose of the present study was to investigate the role of central arginine vasopressin (AVP) in corticotropin releasing hormone (CRH)-induced fever in the rat. Guide cannulae were inserted into the third ventricle and placed over the ventral septal area (VSA). The content of arginine vasopressin in the VSA of the brain was determined by radioimmunoassay. Colon temperature was monitored in lightly restrained rats by insertion of a catheter-mounted thermistor probe 5 cm in the rectum. The results demonstrated that intracerebroventricular (icv) injection of CRH increased AVP level in the VSA and the colonic temperature of the rats. Microinjection of AVP V 1 antagonist into the VSA 10 min before CRH administration significantly enhanced CRH-induced febrile response, while AVP V 1 antagonist itself did not have a significant effect on the colonic temperature. Furthermore, injection of AVP into the VSA 5 min before CRH administration (icv) suppressed the fever evoked by CRH. These findings suggest that CRH is an important factor that stimulates the release of AVP in the VSA during fever, and endogenous AVP in the VSA has an antipyretic action on the CRH-induced fever.

关 键 词：促肾上腺皮质激素释放激素 精氨酸加压素 发热 体温调节 中枢 

分 类 号：R364[医药卫生—病理学]