脑血管病病人血清中补体成份的测定和临床意义  

DETERMINATION AND CLINICAL SIGNIFICANCE OF SERUM COMPLEMENTS IN PATIENTS WITH CEREBROVASCULAR DISEASES

作　　者：张晨[1] 耿新杰[2] 陈颖[2] 于秀英[2] 王守亮[2] 裴海涛 

机构地区：[1]青岛医学院附属医院神经科 [2]青岛医学院附属医院检验科

出　　处：《青岛医学院学报》1991年第4期292-295,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：应用免疫单向扩散法对75例脑血管病病人及32例正常人血清中多项补体成份进行了测定。结果显示,脑血栓形成病人补体C_3含量明显降低,而C_(1q),C_5和B因子的含量明显升高,同时还发现血小板活性亢进,与对照组相比有显著性差异。脑动脉硬化和脑出血患者除B因子的含量较对照组明显升高外,其余4种补体成份均无明显变化。提示补体成份对免疫复合物清除能力的低下和促进血小板活性的增强可能是导致血栓形成的重要原因。Determination of serum complements were carried out in 75 patients with cerebro- vascular diseases and 32 normal controls. Among the patients were 26 with cerebral atherosclerosis, 34 with cerebral thrombosis and 15 with cerebral hemorrhage. The results showed that the levels of C_1 q, C_5 and B factor in the cases of thrombosis were signi- ficantly higher, and the levels of C_3 were significantly lower than those of the control group (P<0.001, P<0.05, P<0.001 and P<0.01 resqectively). Determination of β-thromboglobulin (β-TG) and platelet factor 4 (PF4) was also carried out in 16 patients with cerebral thrombosis. It was found that their levels of β-TG and PF_4 were significantly higher than those of the control group (P<0.01) and their values of C_1 q and C_5 were positively correlated with the levels of β-TG and PF4. These results suggest that the complement system, especially the C_1 q and C_5, could induce the platelet to aggregate and release and might be the risk factors in the formation of cerebral thrombi

关 键 词：脑血管病 血清 补体成份 血小板 

分 类 号：R743.03[医药卫生—神经病学与精神病学]