生长抑素8肽抑制后发性白内障的动物实验  

Experimental study on inhibition of posterior capsule opacification by sandostatin.

作　　者：王国军[1] 张凤妍[2] 李秋明[2] 

机构地区：[1]郑州大学医学院,450052 [2]郑州大学第一附属医院眼科

出　　处：《眼科研究》2001年第6期489-490,共2页Chinese Ophthalmic Research

摘　　要：目的　研究生长抑素 8肽 (SS 8肽 )对兔后囊混浊的影响 ,探讨防治后囊混浊的药物。方法　选择新西兰大白兔 2 9只 ,随机分为 4组 ,对照组、SS 8肽 10 - 6 mol/L组、10 - 7mol/L组、10 - 8mol/L组 ,均行常规的白内障囊外摘出联合后房型人工晶状体植入术 ,实验组灌注液中分别加入不同浓度的SS 8肽 ,术后随访 3个月 ,观察后囊混浊、角膜内皮及切口愈合情况。结果　SS 8肽 10 - 6 mol/L组、10 - 7mol/L组与对照组相比 ,均能显著降低兔后囊混浊的发生率 ,对切口愈合无明显影响 ,可引起个别角膜内皮细胞增大。结论　SSObjectiveTo study the effects of sandostatin on posterior capsule opacification (PCO) and to detect the function of the medicine to prevent PCO in the rabbits.Method29 New Zealand albino rabbits were randomly divided into 4 groups and routinely operated by extracapsular cataract extraction and posterior chamber intraocular lens implantation.The irrigation solutions of 10 -6 mol/L,10 -7 mol/L and 10 -8 mol/L sandostatin were used in 3 experimental groups,respectively.PCO and cornea endothelia and situation of wound healing of the rabbits were observed in 3 months of postoperation.Results10 -6 mol/L and 10 -7 mol/L sandostatin groups were compared with control group,the incidence of PCO was significantly decreased ( P <0 05).sandostatin did not affect on wound healing obviously and made some endothelium cells enlarge.Conclutionsandostatin maybe prevent PCO formation.

关 键 词：兔 生长抑素8肽 后囊混浊 后发性白内障 动态实验 

分 类 号：R776[医药卫生—眼科]