垂体瘤中血小板粘附分子表达及其意义  

Study on the expression and its significance of CD31 in human pituitary adenomas

作　　者：王建桢[1] 付瑞锋 宋乐[1] 臧卫东[3] 牛光明[1] 娄季宇[1] 孙二平 

机构地区：[1]郑州大学第二附属医院神经科,郑州450003 [2]中原油田总医院第二分院外科,濮阳457000 [3]郑州大学医学院人体解剖教研室,郑州450052 [4]河南省西平县人民医院,462100

出　　处：《河南实用神经疾病杂志》2001年第5期4-5,共2页Henan Journal of Practical Nervous Diseases

摘　　要：目的 :探讨垂体瘤中血小板粘附分子 (CD31)的表达及其意义。方法 :应用免疫组化法对 2 0例复发、2 6例未复发的人脑垂体瘤中CD31表达进行检测。结果 :复发组垂体瘤中CD31表达较未复发组明显增高 ,两组有显著性差异 (P <0 0 1)。结论 :肿瘤新生血管形成在垂体瘤发生、发展中起重要作用 。Objective:To study the expression and its significance of CD31 in human pituitary adenomas.Methods:The expression of CD31 was detected in 20 recurrent cases and 26 non-recurrent cases with immunohistochemical method.Results:The expression of CD31 in recurrent cases was higher than that of non-recurrent cases, and there was significant difference between the two groups(P<0 01).Conclusion:Angiogenesis may play an important role in the tumoriogenesis and development of human pituitary adenomas,it may related to recurrence of pituitary adenomas.

关 键 词：垂体瘤 血小板粘附分子 基因表达 CD31 

分 类 号：R736.4[医药卫生—肿瘤]