高血压病和脑卒中患者内源性VitC、E的测定及其意义  

The determination and clinical significance of endogenous vitamin C and vitamin E in patients with hypertension and stroke

作　　者：袁林 李培[2] 

机构地区：[1]贵阳市第二人民医院内科,贵州省贵阳市550002 [2]贵阳医学院老年病研究所

出　　处：《心血管康复医学杂志》2001年第1期5-6,共2页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的 :探讨高血压病和脑卒中患者内源性维生素 C、E的抗氧化作用。方法 :应用紫外分光光度法测定 2 3例高血压病患者、 30例高血压性脑出血患者、 2 5例缺血性脑卒中患者和 2 0例正常对照组的血清维生素 C、E,超氧化物岐化酶 (SOD)和丙二醛 (MDA)的含量。结果 :与正常对照组对比 ,高血压病组 :维生素 C、 E,SOD、 MDA水平无明显改变 ;脑出血、脑缺血组急性期 :维生素 C、E、SOD含量明显降低 (P<0 .0 1) ,MDA水平明显升高(P<0 .0 1) ;恢复期 :维生素 C、 E含量恢复正常 ,SOD含量仍降低 (P<0 .0 5 ) ,MDA仍增高 P<0 .0 5 )。结论 :在脑卒中急性期患者维生素 C、 E水平明显降低 ,但随着病情好转逐渐恢复正常 ,同时伴随 SOD、MDA水平改变。Objective:To study clinical significance of endogenous vitamin C 、E in patients with hypertension and stroke.Methods:The serum vitamin C、E,Malondialdehyde(MDA),superoxide dismutase(SOD) were determined by ultraviolet spectrophotometry in patients with hypertension(23 cases)、hypertensive cerebral hemorrhage (CH,30 cases)、ischemic cerebrovascular disorders(IC,25 cases) and control groups(20 cases).Results:Compared with control group,at acute stage of stroke,the Vit C、E and SOD levels significantly reduced( P <0 01),the MDA level significantly increased( P <0 01);at convalescent stage,the Vit C、E gradually recover to normal,the SOD still reduced( P <0 05),the MDA still incresed( P <0 05).Conclusion:The endogenous Vit C、E have significant change in patients with acute stage of stroke,it gradually recovers to normal in convalescent stage.Meanwhile the SOD and MDA change accordingly.

关 键 词：高血压病 脑卒中 维生素C 维生素E 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R544.1[医药卫生—临床医学]