高血压病并发脑梗死患者红细胞变形性及细胞膜ATP酶活性的研究  

Alteration of erythrocyte deformability and adenosine triphosphatase activity of cell membrane in essential hypertensive patients complicated with cerebral infarction

作　　者：史瑞英[1] 周宏研[1] 孙明[2] 

机构地区：[1]黑龙江省大庆油田总医院,黑龙江省大庆市163000 [2]湖南医科大学湘雅医院心内科

出　　处：《心血管康复医学杂志》2001年第1期17-19,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的 :研究高血压病 (EH)及并发脑梗死 (HCI)患者红细胞变形性 (RCD)及细胞膜 ATP酶活性的改变。方法 :采用粘度法、化学比色法测定了 2 0例正常人、 30例 EH及 30例 HCI患者的红细胞变形指数 (DI)、红细胞膜Na+ ,K+ - ATP酶和 Ca2 + - ATP酶的活性。结果 :(1) EH组与正常对照组相比 ,DI值显著升高 ,ATP酶活性降低 ,EH患者 DI与 ATP酶活性呈负相关 ,与 DBP呈正相关 ;(2 ) HCI组与 EH组相比 ,DI显著升高 ,ATP酶活性显著降低 ;HCI患者 DI与 ATP酶活性呈负相关。结论 :(1) EH患者 RCD降低 ,并与细胞膜 ATP酶活性降低及血压升高相关 ;(2 ) RCD降低可能与 EH患者脑梗死的发生有关。Objective:To investigate the alteration of red cell deformability(RCD) and adenosine triphosphatase(ATPase) activity of cell membrane in essential hypertensive(EH) patients and essential hypertension patients complicated with cerebral infarction(HCI).Methods:Twenty healthy individuals,30 EH patients and 30 HCI patients were selected as subjects.The erythrocyte deformability indexes(DI)、Na +,K +\|ATPase and Ca 2+ ATPase activities were examined.Results:(1)EH patients had significantly higher DI,lower ATPase activity as compared to healthy individuals.There were significantly negative correlation between DI and ATPase activity,and a significantly positive correalation between DI and diastolic blood pressure in EH patients;(2)There was significantly higher DI,lower ATPase activity in HCI patients than those in EH patients.There was significantly negative correlation between DI and ATPase activity in HCI patients.Conclusion:(1)RCD decreases in EH patients,and RCD is correlated to the decreased ATPase of cell membrane and elevated blood pressure;(2)The decreased RCD level may be related to the occurrence of HCI.

关 键 词：高血压 红细胞变形性 三磷酸腺苷 ATP 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]