不同喂酒量对大鼠血浆同型半胱氨酸的影响  

Effect of Alcohol Consumption on Plasma Homocysteine Level in Rats

作　　者：崔连奇[1] 张新[1] 张永生[1] 陈丽芳[1] 强琳[1] 

机构地区：[1]解放军401医院神经科,山东青岛266071

出　　处：《中国慢性病预防与控制》2001年第6期245-246,共2页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨不同酒量对血浆同型半胱氨酸的影响。方法 Wistar雄性大鼠 30只 ,随机分 3组 ,每组 10只。分别给食用酒精 0、0 .7、2 .1g/ kg/ d,连续 3月。3月末采血取血浆高压液相层析法测定血浆同型半胱氨酸浓度。数据统计学处理采用 SPSS10 .0软件 One- Way ANOVA、S- N- K。结果只有饲喂酒精 2 .1g/ kg/ d大鼠 ,血浆同型半胱氨酸浓度升高 ,与对照组差异有统计学意义。结论喂酒量不同对血浆同型半胱氨酸浓度影响不同。大量喂酒使血浆同型半胱氨酸浓度增加 ,而中等量喂酒对血浆同型半胱氨酸浓度无影响。ObjectiveTo investigate the effect of alcohol consumption on plasma homocysteine level.MethodsThirty male Wistar rats randomly averaged into 3 groups were fed the alcohol 0,0.7,2.1 g/kg/d respectively.At the end of 3 months,the plasma samples were taken and stored at -70℃ and then analyzed by HPLC method. Data were analyzed by One-Way ANOVA,Student-Newman-Keuls with SPSS 10.0 software .ResultsHomocysteine contents were significantly increased only in the 2.1 g/kg/d alcohol-fed rats,compared to that in the nonalcohol group.ConclusionHeavy alcohol feeding led to hyperhomocysteinemic, but intermediates alcohol feeding didn't.

关 键 词：同型半胱氨酸 酒精 大鼠 

分 类 号：R743.302[医药卫生—神经病学与精神病学]