海嘧啶对肿瘤细胞膜钠泵活性的影响  

The influence of the sea pyrimidine on the activities of natrium pump at tumor cells' membrance

作　　者：王志举[1] 季宇彬[2] 章茜[1] 乔鹏[1] 

机构地区：[1]郑州大学医学院生理教研室,河南郑州450052 [2]哈尔滨商业大学制药工程系,黑龙江哈尔滨150076

出　　处：《河南医学研究》2001年第3期197-199,共3页Henan Medical Research

基　　金：国家科委生命中心博士基金资助 (96-90 1 -0 6-1 0 );中国优秀博士后基金资助;中博基 [1 997]1 7号 ;黑龙江省杰出青年基金资助J990 6;黑龙江省自然科学基金项目资助(D980 1 )。

摘　　要：目的 :观察海嘧啶对小白鼠实体型肿瘤 (S180 )和腹水型肿瘤 (EAC、H2 2 )细胞膜钠泵活性的影响。方法 :荷瘤小鼠分为治疗组和对照组 ,分别测定各组瘤细胞膜钠泵活性。结果 :海嘧啶对小鼠S180 、EAC及H2 2 肿瘤细胞膜钠泵活性有明显的抑制作用。结论 :海嘧啶抗肿瘤的药理机制与其能够抑制肿瘤细胞膜钠泵活性有关。Objective: To observe the effect of the sea Pyrimidine on the activities of natrium pump at cells' membrance of S 180 ,EAC and H 22 .Methods: Mice were divided into 2 groups:treat group and control group,and the activities of natrium pump at tumor cells' membrance was examined respectively.Results: Sea primidine can reduce the activities of natrium pump at tumor cells' membrance.Conclusion: The anti tumor pharmacologic mechanism of the sea pyrimidine is related to it's decreasing the activities of natrium pump at tumor cells' membrance.

关 键 词：海嘧啶 肿瘤细胞膜 钠泵活性 癌变机制 药理 

分 类 号：R730.2[医药卫生—肿瘤] R979.1[医药卫生—临床医学]