nm23-H_1基因蛋白在膀胱癌的表达及临床意义  

Expression of nm23-H_1 gene protein in bladder carcinoma and the clinical significance

作　　者：张钢[1] 解肖冰[1] 张绍增[1] 张淑萍[1] 

机构地区：[1]兰州军区兰州总医院泌尿外科,甘肃兰州730050

出　　处：《西北国防医学杂志》2002年第1期30-31,T001,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的 :探讨肿瘤抑制基因nm2 3-H1在膀胱中的表达及临床意义。方法 :应用免疫组织化学S -P法检测 18例正常膀胱组织中及 38例膀胱移行细胞癌组织中nm2 3-H1的表达。结果 :nm2 3-H1在正常膀胱组织、膀胱癌中阳性表达率分别为83.3%(15 / 18) ,44 .7%(17/ 38)。二者间有显著差异 (P <0 .0 1)。提示nm2 3-H1阳性表达率与膀胱移行细胞癌的临床分期、临床分级、肿瘤大小及是否转移有密切关系。结论 :nm2 3-H1在膀胱癌中的阳性表达对抑制肿瘤生长 ,浸润和转移起重要作用 ,可作为膀胱癌患者预测转移和预后及判断膀胱移行细胞癌生物学行为的良好指标。Objective:To study the expression and clinical significance of nm23-H 1 in human bladder carcinoma.Methods:Immunohistochemistry method was used to detect nm23-H 1 expression in 18 normal bladder tissues and 38 primary bladder carcinoma tissues.Results:The positive expression rates of nm23-H 1 in normal bladder tissues and primary bladder carcinoma tissues were 83.5% and 44.7% respectively.There was a significant difference(P<0.01).The positive expression rate of nm23-H 1 was closely correlated with clinicopathologic stages,pathological grades,tumor size and metastasis.Conclusion:Expression of nm23-H 1 in bladder carcinoma plays an important role in suppression of invasive growth and metastasis of tumor.It might be a good indicator to predict metastasis and prognosis and to evaluate the biological behavior of bladder carcinoma.

关 键 词：膀胱肿瘤 nm23-H1基因蛋白 免疫组织化学 临床 

分 类 号：R737.14[医药卫生—肿瘤]