血链球菌对兔血细胞、血压及心电图的影响  

Effects of Streptococcus sanguis on blood composition, blood pressure and cardiac dysfunction in rabbis

作　　者：陈晖[1] 赵孟辉[2] 李菊花[3] 邓淑丽[1] 

机构地区：[1]浙江大学医学院附属口腔医院口腔内科,杭州310031 [2]浙江大学医学院附属口腔医院机能中心,杭州310031 [3]浙江大学医学院附属口腔医院营养系,杭州310031

出　　处：《中华口腔医学杂志》2001年第5期354-356,共3页Chinese Journal of Stomatology

基　　金：浙江省科委科研基金资助项目 ( 97110 312 9)

摘　　要：目的　观察凝集阳性的血链球菌 (S s)进入兔血循环后 ,对心脏及血液成分的影响。方法　将血链球菌 13 3 79菌株 3× 10 9浓度于兔耳缘静脉注入其体内 ,并分别在注射前和注射后 5、10、2 0、3 0、4 5及 60min时测定外周血血小板、白细胞数量的变化以及血压和心电图变化。结果　注射S s13 3 79后 ,所测时段的血小板及白细胞量均有明显改变 ,P <0 0 1(n =12 )。心电图也表明有短时异常 ,S T段下移 >0 5mV ,Q T时间延长。血压表现为先上升 ,后下降。结论　血链球菌株 13 3 79在血循环内能引起心肌缺血及血压变化 ,外周血小板和白细胞明显减少。Objective To investigate effect of streptococcus sanguis on blood cell and cardiopulmo nary changes. Methods 133-79 strains of streptococcus sangu is (aggregation positive phenotype) were infused intravenously into rabbits. Before and 5, 10, 20, 30, 45, 60 min after infuse platelets count, leukocytes c ount, blood pressure and ECG were measured. Results After infus ed intravenously, both platelets and leukocytes count decreased remarkably (P <0.01, n=12). The ECG showed ST segment depression (>0.05 mV). Diphasi c blo od pressure occurred (first hypertensive then hypotensive). Conclusions Streptococcus sanguis 133-79 strains in circulation system might cause myocardial ischemia, blood pressure changes, peripheral circulation platel ets and leukocytes decrease remarkably.

关 键 词：口腔菌斑 链球菌 血 血细胞 血压 心电图 

分 类 号：R780.2[医药卫生—口腔医学]