卵巢肿瘤组织谷胱甘肽S转移酶的表达与临床及病理因素的关系  

The Relationship between the Expression of Glutathione Stransferase л in Ovarian Tumor and the Clinical and Pathological Date

作　　者：李春荣[1] 程鸾[1] 宋志琴[1] 尹善德[1] 刘江 

机构地区：[1]海军总医院妇产科,北京100037 [2]伊春市乌马河林业局医院妇产科

出　　处：《肿瘤防治研究》2001年第6期434-435,共2页Cancer Research on Prevention and Treatment

摘　　要：目的　检测卵巢肿瘤组织中谷胱甘肽S转移酶 (GST л)的表达 ,探讨其与临床及病理的关系。方法　采用免疫组化SP法检测 77例卵巢恶性肿瘤 ,30例卵巢良性肿瘤中GST π的表达。结果 (1)卵巢恶性肿瘤术前接受化疗组GST π阳性表达率 5 2 .38% ,未接受化疗组 32 .14% ,卵巢良性肿瘤组 6 .6 7% ,三组比较有显著性差异 (P <0 .0 1)。 (2 )低分化肿瘤较高、中分化者GST л阳性表达率显著增高 (P <0 .0 1)。结论　卵巢恶性肿瘤组织中GST л表达与其化疗有关 ,对临床判断化疗敏感性和预后有一定参考价值。Objective To study the relationship between the expression of glutathione stransferase л(GST л)in ovarian cancer tissue and the clinical and pathological result.Methods The expression of GST л in 77 cases of ovarian cancer, 30 ovarian benign tumors was determined by using immunohistochemical SP method.Results (1)Positive expression with GST л was 52.38% in malignant tumors having chemotherapy before operations, 32.14% in having no chemotherapy and 6.67% in benign ovarian tumors( P<0.01 ).(2)The expression of GST л was significantly higher in poor differentiation malignant than others( P<0.01 ).Conclusion The expression of GST л in patients with ovarian carcinoma is closy related to the chemo sensitivities and the prognosis of the disease.

关 键 词：卵巢肿瘤 谷胱甘肽转移酶类 耐药性 预后 病理 

分 类 号：R737.31[医药卫生—肿瘤]